{"doi":"10.1126/sciimmunol.ads1556","title":"Suppression of thrombospondin-1–mediated inflammaging prolongs hematopoietic health span","abstract":"Chronic low-grade inflammation observed in older adults, termed inflammaging, is a common feature underlying a multitude of aging-associated maladies including a decline in hematopoietic activity. However, whether suppression of inflammaging can preserve hematopoietic health span remains unclear, in part because of a lack of tools to measure inflammaging within hematopoietic stem cells (HSCs). Here, we identify thrombospondin-1 (Thbs1) as an essential regulator of inflammaging within HSCs. We describe a transcriptomics-based approach for measuring inflammaging within stem cells and demonstrate that deletion of Thbs1 is sufficient to prevent HSC inflammaging. Our results demonstrate that suppression of HSC inflammaging prevents aging-associated defects in hematopoietic activity including loss of HSC self-renewal, myeloid-biased HSC differentiation, and anemia. Our findings indicate that suppression of HSC inflammaging may also prolong overall systemic health span.","journal":"Science Immunology","year":2025,"id":511935,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":295410,"name":"Michael Gutkin","orcid":"0009-0008-7906-1696","position":1,"is_corresponding":false},{"id":295408,"name":"Michael G. Poulos","orcid":"0000-0002-7622-9966","position":2,"is_corresponding":false},{"id":1033118,"name":"Agatha Winiarski","orcid":"0000-0002-8352-0671","position":3,"is_corresponding":false},{"id":1370755,"name":"Arianna Smith","orcid":"0009-0002-8443-8239","position":4,"is_corresponding":false},{"id":1070807,"name":"Cody Carter","orcid":"0009-0004-0946-6816","position":5,"is_corresponding":false},{"id":1033853,"name":"Chelsea Doughty","orcid":null,"position":6,"is_corresponding":false},{"id":1033852,"name":"Taylor Tillery","orcid":null,"position":7,"is_corresponding":false},{"id":109218,"name":"David Redmond","orcid":"0000-0002-0983-8606","position":8,"is_corresponding":false},{"id":295414,"name":"Ana G. Freire","orcid":"0000-0001-9527-6082","position":9,"is_corresponding":false},{"id":589703,"name":"Jason M. Butler","orcid":"0000-0002-8630-9038","position":10,"is_corresponding":false},{"id":296850,"name":"Pradeep Ramalingam","orcid":null,"position":0,"is_corresponding":true}],"reference_count":112,"raw_metadata":null,"created_at":"2026-07-19T02:48:01.269605Z","pmid":"39752538","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}