{"doi":"10.1126/sciimmunol.adp7193","title":"ATF4 drives regulatory T cell functional specification in homeostasis and obesity","abstract":"Regulatory T cells (T regs ) have diverse functional specification in homeostasis and disease. However, how liver T regs function and are transcriptionally regulated in obesity is not well understood. Here, we identified that effector T regs expressing activating transcription factor 4 (ATF4) were enriched in the livers of obese mice. ATF4 was critical for driving an effector T reg transcriptional program, and ATF4-expressing T regs promoted the development of obesity-induced liver fibrosis by enhancing transforming growth factor–β activation via integrin αvβ8. T reg -specific deletion of Atf4 resulted in reduced liver T regs and attenuation of obesity-induced liver abnormalities. Furthermore, ATF4 was required to promote the differentiation of nonlymphoid tissue T reg precursors under steady state. These findings demonstrate that ATF4 is important for regulating T reg functional specification in homeostasis and obesity.","journal":"Science Immunology","year":2025,"id":512417,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1090352,"name":"Andrea Farrell","orcid":"0009-0003-4993-0364","position":1,"is_corresponding":false},{"id":1007728,"name":"Enchen Zhou","orcid":"0000-0002-3739-4934","position":2,"is_corresponding":false},{"id":1292825,"name":"Houji Qin","orcid":null,"position":3,"is_corresponding":false},{"id":1292355,"name":"Zixuan Zeng","orcid":"0009-0009-6420-7098","position":4,"is_corresponding":false},{"id":1371913,"name":"Kailun Zhou","orcid":"0009-0008-3967-2791","position":5,"is_corresponding":false},{"id":843236,"name":"Karina Cunha e Rocha","orcid":null,"position":6,"is_corresponding":false},{"id":271694,"name":"Dinghong Zhang","orcid":"0000-0002-6291-0750","position":7,"is_corresponding":false},{"id":23911,"name":"Gaowei Wang","orcid":null,"position":8,"is_corresponding":false},{"id":650062,"name":"Amha Atakilit","orcid":"0000-0002-8586-7230","position":9,"is_corresponding":false},{"id":12168,"name":"Dean Sheppard","orcid":"0000-0002-6277-2036","position":10,"is_corresponding":false},{"id":236080,"name":"Li‐Fan Lu","orcid":"0000-0002-9727-0036","position":11,"is_corresponding":false},{"id":356538,"name":"Chunyu Jin","orcid":"0000-0002-0596-5704","position":12,"is_corresponding":false},{"id":271696,"name":"Wei Ying","orcid":"0000-0002-4890-7256","position":13,"is_corresponding":false},{"id":1292354,"name":"Ke Wang","orcid":"0009-0004-1657-0531","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:48:06.263458Z","pmid":"40085690","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}