{"doi":"10.1126/sciimmunol.adp1139","title":"Sterile production of interferons in the thymus affects T cell repertoire selection","abstract":"Type I and III interferons (IFNs) are robustly induced during infections and protect cells against viral infection. Both type I and III IFNs are also produced at low levels in the thymus at steady state; however, their role in T cell development and immune tolerance is unclear. Here, we found that both type I and III IFNs were constitutively produced by a very small number of AIRE + murine thymic epithelial cells, independent of microbial stimulation. Antigen-presenting cells were highly responsive to thymic IFNs, and IFNs were required for the activation and maturation of thymic type 1 conventional dendritic cells, macrophages, and B cells. Loss of IFN sensing led to reduced regulatory T cell selection, reduced T cell receptor (TCR) repertoire diversity, and enhanced autoreactive T cell responses to self-antigens expressed during peripheral IFN signaling. Thus, constitutive exposure to IFNs in the thymus is required for generating a tolerant and diverse TCR repertoire.","journal":"Science Immunology","year":2024,"id":418724,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":47,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":864289,"name":"Matouš Vobořil","orcid":"0000-0002-3672-7629","position":1,"is_corresponding":false},{"id":497484,"name":"Oscar Camilo Salgado","orcid":"0000-0002-9363-8649","position":2,"is_corresponding":false},{"id":498424,"name":"S. Thera Lee","orcid":null,"position":3,"is_corresponding":false},{"id":864290,"name":"Ryan J. Martinez","orcid":"0000-0002-2045-8794","position":4,"is_corresponding":false},{"id":616824,"name":"Christine H. O’Connor","orcid":null,"position":5,"is_corresponding":false},{"id":497485,"name":"Elise R. Breed","orcid":"0000-0001-6468-8463","position":6,"is_corresponding":false},{"id":1207221,"name":"Shuya Xuan","orcid":"0000-0002-5869-8785","position":7,"is_corresponding":false},{"id":804170,"name":"Charles R. Roll","orcid":"0000-0002-0726-2076","position":8,"is_corresponding":false},{"id":1207904,"name":"Saumith Bachigari","orcid":null,"position":9,"is_corresponding":false},{"id":1207905,"name":"Hattie Heiland","orcid":null,"position":10,"is_corresponding":false},{"id":250993,"name":"Daniel B. Stetson","orcid":"0000-0002-5936-1113","position":11,"is_corresponding":false},{"id":245459,"name":"Sergei V. Kotenko","orcid":"0000-0001-5694-878X","position":12,"is_corresponding":false},{"id":235914,"name":"Kristin A. Hogquist","orcid":"0000-0001-9963-5687","position":13,"is_corresponding":false},{"id":545558,"name":"K. Maude Ashby","orcid":"0000-0002-6297-5941","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T01:57:09.067930Z","pmid":"39058762","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}