{"doi":"10.1126/sciimmunol.adn1894","title":"Foxo1 regulates intestinal tissue–resident memory CD8 T cell biology in an anatomic compartment– and context-specific manner","abstract":"Tissue-resident memory CD8 T (T RM ) cells serve as a front-line defense against microbial pathogens in barrier and mucosal tissues. Accurately predicting the roles of tissue-specific transcription factors (TFs) that regulate T RM biology remains a challenge. Here, by applying integrated transcriptomic and epigenomic analyses, we have identified an unexpected role for forkhead box O1 (Foxo1), a TF previously known to regulate circulating memory T cells, in intestinal T RM biology. Foxo1 repressed the maintenance of early small intestinal intraepithelial T RM cells in contrast with its actions in sustaining T RM cells from small intestinal lamina propria and colon and contrary to its broader role in promoting intestinal T RM cell formation. These findings highlight the emerging concept that the transcriptional regulation of T RM cells may be more complex and nuanced than previously appreciated and underscore the utility of integrated transcriptomic and epigenomic analyses in reconstructing TF-regulatory networks.","journal":"Science Immunology","year":2025,"id":515107,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1093608,"name":"Eunice J. Choi","orcid":null,"position":1,"is_corresponding":false},{"id":855515,"name":"William H. Wong","orcid":null,"position":2,"is_corresponding":false},{"id":855514,"name":"Yun Hsuan Lin","orcid":null,"position":3,"is_corresponding":false},{"id":854750,"name":"Sara A. Vandenburgh","orcid":"0009-0007-3074-8326","position":4,"is_corresponding":false},{"id":854748,"name":"Yi Chia Liu","orcid":"0009-0005-4626-3871","position":5,"is_corresponding":false},{"id":854749,"name":"Priscilla Yao","orcid":"0000-0002-4700-6851","position":6,"is_corresponding":false},{"id":855516,"name":"Cynthia S. Indralingam","orcid":null,"position":7,"is_corresponding":false},{"id":43290,"name":"G Yeo","orcid":null,"position":8,"is_corresponding":false},{"id":235441,"name":"Elina I. Zúñiga","orcid":"0000-0001-8699-1623","position":9,"is_corresponding":false},{"id":61594,"name":"Ananda W. Goldrath","orcid":"0000-0002-5900-508X","position":10,"is_corresponding":false},{"id":228323,"name":"Wei Wang","orcid":"0000-0003-4377-5060","position":11,"is_corresponding":false},{"id":225253,"name":"John T. Chang","orcid":"0000-0003-0873-6218","position":12,"is_corresponding":false},{"id":854747,"name":"Paul Wei‐Che Hsu","orcid":"0000-0001-9365-9565","position":0,"is_corresponding":true}],"reference_count":92,"raw_metadata":null,"created_at":"2026-07-19T02:48:34.431522Z","pmid":"40215325","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}