{"doi":"10.1126/sciimmunol.adk8141","title":"Lymphatic vessel transit seeds cytotoxic resident memory T cells in skin draining lymph nodes","abstract":"Lymphatic transport shapes the homeostatic immune repertoire of lymph nodes (LNs). LN-resident memory T cells (T RMs ) play an important role in site-specific immune memory, yet how LN T RMs form de novo after viral infection remains unclear. Here, we tracked the anatomical distribution of antiviral CD8 + T cells as they seeded skin and LN T RMs using a model of vaccinia virus–induced skin infection. LN T RMs localized to the draining LNs (dLNs) of infected skin, and their formation depended on the lymphatic egress of effector CD8 + T cells from the skin, already poised for residence. Effector CD8 + T cell transit through skin was required to populate LN T RMs in dLNs, a process reinforced by antigen encounter in skin. Furthermore, LN T RMs were protective against viral rechallenge in the absence of circulating memory T cells. These data suggest that a subset of tissue-infiltrating CD8 + T cells egress from tissues during viral clearance and establish a layer of regional protection in the dLN basin.","journal":"Science Immunology","year":2024,"id":426029,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9464,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1161699,"name":"Austin C. Schultz","orcid":"0009-0000-2406-8497","position":1,"is_corresponding":false},{"id":1018641,"name":"Ines Delclaux","orcid":"0009-0001-6420-2934","position":2,"is_corresponding":false},{"id":1165181,"name":"Vanessa Cristaldi","orcid":"0000-0001-7345-3383","position":3,"is_corresponding":false},{"id":465805,"name":"Madeline J. Churchill","orcid":"0000-0001-7624-4894","position":4,"is_corresponding":false},{"id":632061,"name":"Katherine S. Ventre","orcid":"0000-0002-7675-7355","position":5,"is_corresponding":false},{"id":516590,"name":"Amanda W. Lund","orcid":"0000-0001-7389-9983","position":6,"is_corresponding":false},{"id":829481,"name":"Taylor A. Heim","orcid":"0000-0003-4128-5754","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:58:37.924718Z","pmid":"38848340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}