{"doi":"10.1126/sciimmunol.adj7029","title":"T cell help shapes B cell tolerance","abstract":"T cell help is a crucial component of the normal humoral immune response, yet whether it promotes or restrains autoreactive B cell responses remains unclear. Here, we observe that autoreactive germinal centers require T cell help for their formation and persistence. Using retrogenic chimeras transduced with candidate TCRs, we demonstrate that a follicular T cell repertoire restricted to a single autoreactive TCR, but not a foreign antigen-specific TCR, is sufficient to initiate autoreactive germinal centers. Follicular T cell specificity influences the breadth of epitope spreading by regulating wild-type B cell entry into autoreactive germinal centers. These results demonstrate that TCR-dependent T cell help can promote loss of B cell tolerance and that epitope spreading is determined by TCR specificity.","journal":"Science Immunology","year":2024,"id":426342,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9515,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":870343,"name":"Xihui Yin","orcid":"0000-0002-1861-1147","position":1,"is_corresponding":false},{"id":366921,"name":"Tyler R. Prestwood","orcid":"0000-0002-0971-5286","position":2,"is_corresponding":false},{"id":1079923,"name":"Minghe Ma","orcid":"0000-0002-4496-6240","position":3,"is_corresponding":false},{"id":22091,"name":"Paul J. Utz","orcid":"0000-0003-1181-1565","position":4,"is_corresponding":false},{"id":16703,"name":"Michael C. Carroll","orcid":"0000-0002-3213-4295","position":5,"is_corresponding":false},{"id":6942,"name":"Elliot H. Akama‐Garren","orcid":"0000-0002-1690-2055","position":0,"is_corresponding":true}],"reference_count":122,"raw_metadata":null,"created_at":"2026-07-19T01:58:37.924718Z","pmid":"38363829","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}