{"doi":"10.1126/sciimmunol.adi7038","title":"Intestinal tuft cell immune privilege enables norovirus persistence","abstract":"The persistent murine norovirus strain MNV CR6 is a model for human norovirus and enteric viral persistence. MNV CR6 causes chronic infection by directly infecting intestinal tuft cells, rare chemosensory epithelial cells. Although MNV CR6 induces functional MNV-specific CD8 + T cells, these lymphocytes fail to clear infection. To examine how tuft cells promote immune escape, we interrogated tuft cell interactions with CD8 + T cells by adoptively transferring JEDI (just EGFP death inducing) CD8 + T cells into Gfi1b-GFP tuft cell reporter mice. Unexpectedly, some intestinal tuft cells partially resisted JEDI CD8 + T cell–mediated killing—unlike Lgr5 + intestinal stem cells and extraintestinal tuft cells—despite seemingly normal antigen presentation. When targeting intestinal tuft cells, JEDI CD8 + T cells predominantly adopted a T resident memory phenotype with decreased effector and cytotoxic capacity, enabling tuft cell survival. JEDI CD8 + T cells neither cleared nor prevented MNV CR6 infection in the colon, the site of viral persistence, despite targeting a virus-independent antigen. Ultimately, we show that intestinal tuft cells are relatively resistant to CD8 + T cells independent of norovirus infection, representing an immune-privileged niche that can be leveraged by enteric microbes.","journal":"Science Immunology","year":2024,"id":422903,"datarank":0.4887144807032224,"base_score":3.258096538021482,"endowment":3.258096538021482,"self_citation_contribution":0.4887144807032224,"citation_network_contribution":0.0,"self_endowment_contribution":0.4887144807032224,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9568,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":693509,"name":"Eric Fagerberg","orcid":"0000-0003-0313-3717","position":1,"is_corresponding":false},{"id":513926,"name":"Patrick W. Darcy","orcid":null,"position":2,"is_corresponding":false},{"id":875339,"name":"Gabriel M. Barrón","orcid":"0000-0002-1442-5072","position":3,"is_corresponding":false},{"id":110485,"name":"Renata B. Filler","orcid":"0000-0001-8579-8418","position":4,"is_corresponding":false},{"id":107015,"name":"Mia Madel Alfajaro","orcid":"0000-0002-6402-2730","position":5,"is_corresponding":false},{"id":1217856,"name":"Nicole M D'Angelo-Gavrish","orcid":null,"position":6,"is_corresponding":false},{"id":1217393,"name":"Fang Wang","orcid":"0000-0002-2604-4429","position":7,"is_corresponding":false},{"id":110481,"name":"Vincent R. Graziano","orcid":"0000-0003-1046-9753","position":8,"is_corresponding":false},{"id":404457,"name":"Bridget L. Menasché","orcid":"0000-0003-3520-2422","position":9,"is_corresponding":false},{"id":579397,"name":"Martina Damo","orcid":"0000-0002-7217-3221","position":10,"is_corresponding":false},{"id":638709,"name":"Yating Wang","orcid":"0000-0002-5057-4083","position":11,"is_corresponding":false},{"id":39707,"name":"Michael R. Howitt","orcid":"0000-0002-3643-2468","position":12,"is_corresponding":false},{"id":680249,"name":"Sanghyun Lee","orcid":"0000-0002-0736-1648","position":13,"is_corresponding":false},{"id":499816,"name":"Nikhil S. Joshi","orcid":"0000-0002-7045-7837","position":14,"is_corresponding":false},{"id":66190,"name":"Daniel Mucida","orcid":"0000-0002-0000-0452","position":15,"is_corresponding":false},{"id":107022,"name":"Craig B. Wilen","orcid":"0000-0003-2495-9403","position":16,"is_corresponding":false},{"id":110479,"name":"Madison S. Strine","orcid":"0000-0001-8572-1314","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:57:51.642883Z","pmid":"38517952","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}