{"doi":"10.1126/sciimmunol.adf4726","title":"Architects of immunity: How dendritic cells shape CD8 <sup>+</sup> T cell fate in cancer","abstract":"Immune responses against cancer are dominated by T cell exhaustion and dysfunction. Recent advances have underscored the critical role of early priming interactions in establishing T cell fates. In this review, we explore the importance of dendritic cell (DC) signals in specifying CD8 + T cell fates in cancer, drawing on insights from acute and chronic viral infection models. We highlight the role of DCs in lymph nodes and tumors in maintaining stem-like CD8 + T cells, which are critical for durable antitumor immune responses. Understanding how CD8 + T cell fates are determined will enable the rational design of immunotherapies, particularly therapeutic cancer vaccines, that can modulate DC–T cell interactions to generate beneficial CD8 + T cell fates.","journal":"Science Immunology","year":2025,"id":508928,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":61,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9517,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":241050,"name":"Teresa Dinter","orcid":"0000-0003-4764-501X","position":1,"is_corresponding":false},{"id":355292,"name":"Stefani Spranger","orcid":"0000-0003-3257-4546","position":2,"is_corresponding":false},{"id":1361421,"name":"Vidit Bhandarkar","orcid":"0000-0002-6526-4360","position":0,"is_corresponding":true}],"reference_count":228,"raw_metadata":null,"created_at":"2026-07-19T02:47:00.188082Z","pmid":"39823318","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}