{"doi":"10.1126/sciimmunol.ade7530","title":"Context-dependent role of group 3 innate lymphoid cells in mucosal protection","abstract":"How group 3 innate lymphoid cells (ILC3s) regulate mucosal protection in the presence of T cells remains poorly understood. Here, we examined ILC3 function in intestinal immunity using ILC3-deficient mice that maintain endogenous T cells, T helper 17 (T H 17) cells, and secondary lymphoid organs. ILC3s were dispensable for generation of T H 17 and T H 22 cell responses to commensal and pathogenic bacteria, and absence of ILC3s did not affect IL-22 production by CD4 T cells before or during infection. However, despite the presence of IL-22–producing T cells, ILC3s and ILC3-derived IL-22 were required for maintaining homeostatic functions of the intestinal epithelium. T cell–sufficient, ILC3-deficient mice were capable of pathogen clearance and survived infection with a low dose of Citrobacter rodentium . However, ILC3s promoted pathogen tolerance at early time points of infection by activating tissue-protective immune pathways. Consequently, ILC3s were indispensable for survival after high-dose infection. Our results demonstrate a context-dependent role for ILC3s in immune-sufficient animals and provide a blueprint for uncoupling of ILC3 and T H 17 cell functions.","journal":"Science Immunology","year":2024,"id":426577,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9633,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1020109,"name":"Madeline Edwards","orcid":"0000-0003-0134-2806","position":1,"is_corresponding":false},{"id":1225966,"name":"Koichiro Irie","orcid":"0009-0008-1305-9876","position":2,"is_corresponding":false},{"id":628109,"name":"Yiming Huang","orcid":"0000-0003-1932-2803","position":3,"is_corresponding":false},{"id":1225967,"name":"Yoshinaga Kawano","orcid":"0009-0007-5285-4701","position":4,"is_corresponding":false},{"id":433589,"name":"Alexander Tran","orcid":"0000-0001-8863-7652","position":5,"is_corresponding":false},{"id":1225968,"name":"Simona De Michele","orcid":"0000-0003-4892-810X","position":6,"is_corresponding":false},{"id":270227,"name":"Govind Bhagat","orcid":"0000-0001-6250-048X","position":7,"is_corresponding":false},{"id":288479,"name":"Harris H. Wang","orcid":"0000-0003-2164-4318","position":8,"is_corresponding":false},{"id":483517,"name":"Ivaylo I. Ivanov","orcid":"0000-0001-5337-3386","position":9,"is_corresponding":false},{"id":483514,"name":"Leandro P. Araújo","orcid":"0000-0003-4696-692X","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:58:42.796720Z","pmid":"39151019","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}