{"doi":"10.1126/sciimmunol.add8454","title":"Tissue-resident memory T cell maintenance during antigen persistence requires both cognate antigen and interleukin-15","abstract":"Our understanding of tissue-resident memory T (T RM ) cell biology has been largely developed from acute infection models in which antigen is cleared and sterilizing immunity is achieved. Less is known about T RM cells in the context of chronic antigen persistence and inflammation. We investigated factors that underlie T RM maintenance in a kidney transplantation model in which T RM cells drive rejection. In contrast to acute infection, we found that T RM cells declined markedly in the absence of cognate antigen, antigen presentation, or antigen sensing by the T cells. Depletion of graft-infiltrating dendritic cells or interruption of antigen presentation after T RM cells were established was sufficient to disrupt T RM maintenance and reduce allograft pathology. Likewise, removal of IL-15 transpresentation or of the IL-15 receptor on T cells during T RM maintenance led to a decline in T RM cells, and IL-15 receptor blockade prevented chronic rejection. Therefore, antigen and IL-15 presented by dendritic cells play nonredundant key roles in CD8 T RM cell maintenance in settings of antigen persistence and inflammation. These findings provide insights that could lead to improved treatment of chronic transplant rejection and autoimmunity.","journal":"Science Immunology","year":2023,"id":317815,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9567,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":817360,"name":"Qiang Zeng","orcid":"0000-0003-2372-3466","position":1,"is_corresponding":false},{"id":462112,"name":"Daqiang Zhao","orcid":"0000-0003-2582-0112","position":2,"is_corresponding":false},{"id":312244,"name":"Gang Zhang","orcid":"0000-0002-5337-3164","position":3,"is_corresponding":false},{"id":1024809,"name":"Neda Feizi","orcid":null,"position":4,"is_corresponding":false},{"id":662074,"name":"Priyanka Manandhar","orcid":"0000-0003-2868-5286","position":5,"is_corresponding":false},{"id":411632,"name":"Amanda Williams","orcid":"0000-0003-1343-1101","position":6,"is_corresponding":false},{"id":1024138,"name":"Benjamin Popp","orcid":"0000-0003-1644-4039","position":7,"is_corresponding":false},{"id":311637,"name":"Michelle A. Wood","orcid":"0000-0002-1880-4926","position":8,"is_corresponding":false},{"id":286090,"name":"Anthony J. Demetris","orcid":"0000-0002-9582-3733","position":9,"is_corresponding":false},{"id":1024139,"name":"J. Yun Tso","orcid":"0009-0005-7495-5883","position":10,"is_corresponding":false},{"id":256585,"name":"Aaron J. Johnson","orcid":"0000-0002-7921-484X","position":11,"is_corresponding":false},{"id":349057,"name":"Larry Kane","orcid":"0000-0001-5198-516X","position":12,"is_corresponding":false},{"id":462113,"name":"Khodor I. Abou‐Daya","orcid":"0000-0001-8788-2728","position":13,"is_corresponding":false},{"id":548429,"name":"Warren D. Shlomchik","orcid":"0000-0002-0430-9078","position":14,"is_corresponding":false},{"id":311635,"name":"Martin H. Oberbarnscheidt","orcid":"0000-0003-2040-809X","position":15,"is_corresponding":false},{"id":325789,"name":"Fadi G. Lakkis","orcid":"0000-0001-9937-2637","position":16,"is_corresponding":false},{"id":640325,"name":"Roger Tieu","orcid":"0000-0001-9339-5096","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T01:06:55.884740Z","pmid":"37083450","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}