{"doi":"10.1126/sciimmunol.abi9768","title":"An IL-9–pulmonary macrophage axis defines the allergic lung inflammatory environment","abstract":"Despite IL-9 functioning as a pleiotropic cytokine in mucosal environments, the IL-9–responsive cell repertoire is still not well defined. Here, we found that IL-9 mediates proallergic activities in the lungs by targeting lung macrophages. IL-9 inhibits alveolar macrophage expansion and promotes recruitment of monocytes that develop into CD11c + and CD11c − interstitial macrophage populations. Interstitial macrophages were required for IL-9–dependent allergic responses. Mechanistically, IL-9 affected the function of lung macrophages by inducing Arg1 activity. Compared with Arg1-deficient lung macrophages, Arg1-expressing macrophages expressed greater amounts of CCL5. Adoptive transfer of Arg1 + lung macrophages but not Arg1 − lung macrophages promoted allergic inflammation that Il9r −/− mice were protected against. In parallel, the elevated expression of IL-9, IL-9R, Arg1, and CCL5 was correlated with disease in patients with asthma. Thus, our study uncovers an IL-9/macrophage/Arg1 axis as a potential therapeutic target for allergic airway inflammation.","journal":"Science Immunology","year":2022,"id":236095,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":355867,"name":"Jocelyn Wang","orcid":"0000-0003-0016-3136","position":1,"is_corresponding":false},{"id":355871,"name":"Baohua Zhou","orcid":"0000-0003-1156-4517","position":2,"is_corresponding":false},{"id":855882,"name":"Abigail Pajulas","orcid":"0000-0002-1137-1400","position":3,"is_corresponding":false},{"id":29086,"name":"Hongyu Gao","orcid":"0000-0001-8633-3604","position":4,"is_corresponding":false},{"id":335026,"name":"Baskar Ramdas","orcid":"0009-0006-2206-5720","position":5,"is_corresponding":false},{"id":285832,"name":"Byunghee Koh","orcid":"0000-0003-3554-4449","position":6,"is_corresponding":false},{"id":348765,"name":"Benjamin J. Ulrich","orcid":"0000-0002-2729-1798","position":7,"is_corresponding":false},{"id":419559,"name":"Shuangshuang Yang","orcid":"0000-0003-0871-6356","position":8,"is_corresponding":false},{"id":335029,"name":"Reuben Kapur","orcid":"0000-0003-2225-1700","position":9,"is_corresponding":false},{"id":855883,"name":"Jean‐Christophe Renauld","orcid":"0000-0003-1736-2131","position":10,"is_corresponding":false},{"id":348770,"name":"Sophie Paczesny","orcid":"0000-0001-5571-2775","position":11,"is_corresponding":false},{"id":227678,"name":"Yunlong Liu","orcid":"0000-0002-2699-626X","position":12,"is_corresponding":false},{"id":292273,"name":"Robert M. Tighe","orcid":"0000-0002-3465-9861","position":13,"is_corresponding":false},{"id":80230,"name":"Paula Licona-Limón","orcid":"0000-0002-7692-8900","position":14,"is_corresponding":false},{"id":80236,"name":"Richard A. Flavell","orcid":"0000-0003-4461-0778","position":15,"is_corresponding":false},{"id":855884,"name":"Shogo Takatsuka","orcid":"0000-0003-3258-0129","position":16,"is_corresponding":false},{"id":727572,"name":"Daisuke Kitamura","orcid":"0000-0002-5195-0474","position":17,"is_corresponding":false},{"id":355870,"name":"Robert S. Tepper","orcid":"0000-0003-3322-5903","position":18,"is_corresponding":false},{"id":254567,"name":"Jie Sun","orcid":"0000-0002-2347-4511","position":19,"is_corresponding":false},{"id":285837,"name":"Mark H. Kaplan","orcid":"0000-0002-2923-8245","position":20,"is_corresponding":false},{"id":348768,"name":"Yongyao Fu","orcid":"0000-0002-0739-0035","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T00:21:58.728756Z","pmid":"35179949","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}