{"doi":"10.1126/sciimmunol.abc2728","title":"Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding","abstract":"in the peripheral blood of patients with head and neck squamous cell carcinoma, which corresponded with poor prognosis. This correlation was also observed in a cohort of patients with skin cancers and was associated with increased disease progression after standard-of-care immunotherapy. These data suggest that subtle changes in LAG3 inhibitory receptor signaling can act as a resistance mechanism with a substantive effect on patient responsiveness to immunotherapy.","journal":"Science Immunology","year":2020,"id":56338,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":258579,"name":"Ashwin Somasundaram","orcid":"0000-0003-3167-406X","position":1,"is_corresponding":false},{"id":292548,"name":"Jessica Moskovitz","orcid":"0000-0003-2360-6411","position":2,"is_corresponding":false},{"id":255410,"name":"Andrea L. Szymczak-Workman","orcid":"0000-0002-9776-049X","position":3,"is_corresponding":false},{"id":292549,"name":"Chang Liu","orcid":"0000-0001-8924-1772","position":4,"is_corresponding":false},{"id":109265,"name":"Anthony R. Cillo","orcid":"0000-0002-3213-3129","position":5,"is_corresponding":false},{"id":292550,"name":"Lin Huang","orcid":"0000-0002-4892-7871","position":6,"is_corresponding":false},{"id":242168,"name":"Daniel P. Normolle","orcid":"0000-0001-8675-5014","position":7,"is_corresponding":false},{"id":292551,"name":"Kelly D. Moynihan","orcid":"0000-0001-6200-7863","position":8,"is_corresponding":false},{"id":118806,"name":"Ichiro Taniuchi","orcid":"0000-0002-9853-9068","position":9,"is_corresponding":false},{"id":236278,"name":"Darrell J. Irvine","orcid":"0000-0002-8637-1405","position":10,"is_corresponding":false},{"id":247570,"name":"John M. Kirkwood","orcid":"0000-0002-3570-4476","position":11,"is_corresponding":false},{"id":258581,"name":"Evan J. Lipson","orcid":"0000-0003-2976-0911","position":12,"is_corresponding":false},{"id":109277,"name":"Robert L. Ferris","orcid":"0000-0001-6605-2071","position":13,"is_corresponding":false},{"id":109276,"name":"Tullia C. Bruno","orcid":"0000-0002-6433-0207","position":14,"is_corresponding":false},{"id":255411,"name":"Creg J. Workman","orcid":"0000-0002-9964-9509","position":15,"is_corresponding":false},{"id":109278,"name":"Dario A.A. Vignali","orcid":"0000-0002-2771-5992","position":16,"is_corresponding":false},{"id":292547,"name":"Lawrence P. Andrews","orcid":"0000-0002-4923-142X","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T21:05:49.581291Z","pmid":"32680952","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}