{"doi":"10.1126/sciimmunol.abb8786","title":"Transcriptomic and clonal characterization of T cells in the human central nervous system","abstract":"T cells provide critical immune surveillance to the central nervous system (CNS), and the cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further characterization of the state of T cells in the CSF in healthy individuals is important for understanding how T cells provide protective immune surveillance without damaging the delicate environment of the CNS and providing tissue-specific context for understanding immune dysfunction in neuroinflammatory disease. Here, we have profiled T cells in the CSF of healthy human donors and have identified signatures related to cytotoxic capacity and tissue adaptation that are further exemplified in clonally expanded CSF T cells. By comparing profiles of clonally expanded T cells obtained from the CSF of patients with multiple sclerosis (MS) and healthy donors, we report that clonally expanded T cells from the CSF of patients with MS have heightened expression of genes related to T cell activation and cytotoxicity.","journal":"Science Immunology","year":2020,"id":51998,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":143,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9439,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":69461,"name":"Le Zhang","orcid":"0000-0002-4860-831X","position":1,"is_corresponding":false},{"id":261875,"name":"Maggie Pecsok","orcid":"0000-0001-6806-5423","position":2,"is_corresponding":false},{"id":261876,"name":"Kelly Perlman","orcid":"0000-0002-2716-0712","position":3,"is_corresponding":false},{"id":261877,"name":"Chrysoula Zografou","orcid":"0000-0002-2934-2739","position":4,"is_corresponding":false},{"id":261878,"name":"Khadir Raddassi","orcid":"0000-0002-2383-9744","position":5,"is_corresponding":false},{"id":261879,"name":"Ahmad Abulaban","orcid":"0000-0002-2508-9852","position":6,"is_corresponding":false},{"id":254926,"name":"Smita Krishnaswamy","orcid":"0000-0001-5823-1985","position":7,"is_corresponding":false},{"id":261880,"name":"Jack P. Antel","orcid":"0000-0002-5148-0636","position":8,"is_corresponding":false},{"id":107019,"name":"David van Dijk","orcid":"0000-0003-3911-9925","position":9,"is_corresponding":false},{"id":37332,"name":"David A. Hafler","orcid":"0000-0003-4664-535X","position":10,"is_corresponding":false},{"id":261874,"name":"Jenna L. Pappalardo","orcid":"0000-0002-5542-3356","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-18T20:42:26.843314Z","pmid":"32948672","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}