{"doi":"10.1126/sciimmunol.aba8426","title":"All-trans retinoic acid overcomes solid tumor radioresistance by inducing inflammatory macrophages","abstract":"T cells are required for the effectiveness of the IR and RA combination. Combination treatment with RA enhanced the abscopal response when radiation and PD-L1 blockade were used together. The synergistic positive feedback loop of inflammatory macrophages and adaptive immunity is required for the antitumor efficacy of IR plus RA combination treatment. Our findings provide a translational and relatively nontoxic strategy for enhancing the local and systemic antitumor effects of IR.","journal":"Science Immunology","year":2021,"id":156742,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9602,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":632784,"name":"Yuzhu Hou","orcid":"0000-0001-8274-027X","position":1,"is_corresponding":false},{"id":638579,"name":"Xiaona Huang","orcid":"0000-0002-9983-5723","position":2,"is_corresponding":false},{"id":632787,"name":"Liangliang Wang","orcid":"0000-0001-8340-5190","position":3,"is_corresponding":false},{"id":662071,"name":"Jiaai Wang","orcid":"0000-0003-3217-7444","position":4,"is_corresponding":false},{"id":230365,"name":"Wenxin Zheng","orcid":"0000-0002-0682-273X","position":5,"is_corresponding":false},{"id":662734,"name":"Hengjin Yang","orcid":null,"position":6,"is_corresponding":false},{"id":638577,"name":"Xinshuang Yu","orcid":"0000-0001-9095-3435","position":7,"is_corresponding":false},{"id":230366,"name":"Kaiting Yang","orcid":"0000-0001-9328-5655","position":8,"is_corresponding":false},{"id":638580,"name":"Jason Bugno","orcid":"0000-0002-3046-8072","position":9,"is_corresponding":false},{"id":662072,"name":"Xingchen Ding","orcid":"0000-0002-4229-5340","position":10,"is_corresponding":false},{"id":1543,"name":"Everett E. Vokes","orcid":"0000-0002-8645-8068","position":11,"is_corresponding":false},{"id":230370,"name":"Yang‐Xin Fu","orcid":"0000-0001-8441-6617","position":12,"is_corresponding":false},{"id":51398,"name":"Ralph R. Weichselbaum","orcid":"0000-0002-5643-8939","position":13,"is_corresponding":false},{"id":632786,"name":"Hua Liang","orcid":"0000-0001-5512-8595","position":14,"is_corresponding":false},{"id":638578,"name":"Enyu Rao","orcid":"0000-0003-2949-2902","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:44:13.017332Z","pmid":"34723044","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}