{"doi":"10.1126/sciimmunol.aaz4415","title":"M2-like, dermal macrophages are maintained via IL-4/CCL24–mediated cooperative interaction with eosinophils in cutaneous leishmaniasis","abstract":"infected dermis is not clear. Here, we show that, in infected mice lacking IL-4/13 from eosinophils, dermal TRMs shifted to a proinflammatory state, their numbers declined, and disease was attenuated. Intravital microscopy revealed a rapid infiltration of eosinophils followed by their tight interaction with dermal TRMs. IL-4-stimulated dermal TRMs, in concert with IL-10, produced a large amount of CCL24, which functioned to amplify eosinophil influx and their interaction with dermal TRMs. An intraperitoneal helminth infection model also demonstrated a requirement for eosinophil-derived IL-4 to maintain tissue macrophages through a CCL24-mediated amplification loop. CCL24 secretion was confined to resident macrophages in other tissues, implicating eosinophil-TRM cooperative interactions in diverse inflammatory settings.","journal":"Science Immunology","year":2020,"id":55543,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":287786,"name":"Mariana M. Chaves","orcid":"0000-0002-7515-3461","position":1,"is_corresponding":false},{"id":287787,"name":"Olena Kamenyeva","orcid":"0000-0002-6541-5616","position":2,"is_corresponding":false},{"id":287788,"name":"Pedro Henrique Gazzinelli-Guimarães","orcid":"0000-0003-4932-2206","position":3,"is_corresponding":false},{"id":287789,"name":"Byunghyun Kang","orcid":"0000-0002-7935-755X","position":4,"is_corresponding":false},{"id":287790,"name":"Gabriela Pessenda","orcid":"0000-0003-3450-4816","position":5,"is_corresponding":false},{"id":287791,"name":"Katiuska Passelli","orcid":"0000-0002-6785-1323","position":6,"is_corresponding":false},{"id":287792,"name":"Fabienne Tacchini‐Cottier","orcid":"0000-0003-3561-0207","position":7,"is_corresponding":false},{"id":243363,"name":"Juraj Kabát","orcid":"0000-0001-8636-542X","position":8,"is_corresponding":false},{"id":287793,"name":"Elizabeth A. Jacobsen","orcid":"0000-0003-2956-753X","position":9,"is_corresponding":false},{"id":287794,"name":"Thomas B. Nutman","orcid":"0000-0001-6887-4941","position":10,"is_corresponding":false},{"id":287795,"name":"David L. Sacks","orcid":"0000-0002-7557-3124","position":11,"is_corresponding":false},{"id":280956,"name":"Sang Hun Lee","orcid":"0000-0002-0020-4631","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T21:05:29.672878Z","pmid":"32276966","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}