{"doi":"10.1126/sciimmunol.aat7117","title":"Gut T cell–independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells","abstract":"The gut mounts secretory immunoglobulin A (SIgA) responses to commensal bacteria through nonredundant T cell-dependent (TD) and T cell-independent (TI) pathways that promote the establishment of mutualistic host-microbiota interactions. SIgAs from the TD pathway target penetrant bacteria, and their induction requires engagement of CD40 on B cells by CD40 ligand on T follicular helper cells. In contrast, SIgAs from the TI pathway bind a larger spectrum of bacteria, but the mechanism underpinning their production remains elusive. Here, we show that the intestinal TI pathway required CD40-independent B cell-activating signals from TACI, a receptor for the innate CD40 ligand-like factors BAFF and APRIL. TACI-induced SIgA responses targeted a fraction of the gut microbiota without shaping its overall composition. Of note, TACI was dispensable for TD induction of IgA in gut-associated lymphoid organs. Thus, BAFF/APRIL signals acting on TACI orchestrate commensal bacteria-specific SIgA responses through an intestinal TI program.","journal":"Science Immunology","year":2020,"id":57164,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":80,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298206,"name":"Alejo Chorny","orcid":"0000-0001-5874-350X","position":1,"is_corresponding":false},{"id":298207,"name":"Sandra Casas-Recasens","orcid":"0000-0002-5498-3466","position":2,"is_corresponding":false},{"id":300123,"name":"Cindy Gutzeit","orcid":null,"position":3,"is_corresponding":false},{"id":277525,"name":"Gerold Bongers","orcid":"0000-0002-3187-120X","position":4,"is_corresponding":false},{"id":298208,"name":"Irene Thomsen","orcid":"0000-0002-6567-3148","position":5,"is_corresponding":false},{"id":276901,"name":"Lili Chen","orcid":"0000-0003-0026-4877","position":6,"is_corresponding":false},{"id":276900,"name":"Zhengxiang He","orcid":"0000-0002-8961-859X","position":7,"is_corresponding":false},{"id":300124,"name":"Dean B. Matthews","orcid":null,"position":8,"is_corresponding":false},{"id":298209,"name":"Michael A. Oropallo","orcid":"0000-0002-4394-3397","position":9,"is_corresponding":false},{"id":300125,"name":"Pavan K. Veeramreddy","orcid":null,"position":10,"is_corresponding":false},{"id":298210,"name":"Mathieu Uzzan","orcid":"0000-0002-7761-2879","position":11,"is_corresponding":false},{"id":298211,"name":"Arthur Mortha","orcid":"0000-0003-2673-0485","position":12,"is_corresponding":false},{"id":97903,"name":"Jorge Carrillo","orcid":"0000-0003-0221-5948","position":13,"is_corresponding":false},{"id":66192,"name":"Bernardo Sgarbi Reis","orcid":"0000-0002-6841-116X","position":14,"is_corresponding":false},{"id":298212,"name":"Meera Ramanujam","orcid":"0000-0002-8737-5790","position":15,"is_corresponding":false},{"id":298213,"name":"Jordi Sintes","orcid":"0000-0002-1836-7076","position":16,"is_corresponding":false},{"id":232316,"name":"Giuliana Magri","orcid":"0000-0002-0163-3542","position":17,"is_corresponding":false},{"id":298214,"name":"Paul J. Maglione","orcid":"0000-0001-6805-7271","position":18,"is_corresponding":false},{"id":104929,"name":"Charlotte Cunningham‐Rundles","orcid":"0000-0003-0725-0320","position":19,"is_corresponding":false},{"id":298215,"name":"Richard J. Bram","orcid":"0000-0002-5940-6158","position":20,"is_corresponding":false},{"id":105286,"name":"Jeremiah J. Faith","orcid":"0000-0002-2691-4500","position":21,"is_corresponding":false},{"id":105236,"name":"Saurabh Mehandru","orcid":"0000-0001-9781-2969","position":22,"is_corresponding":false},{"id":298216,"name":"Oliver Pabst","orcid":"0000-0002-5533-883X","position":23,"is_corresponding":false},{"id":232317,"name":"Andrea Cerutti","orcid":"0000-0003-3026-4704","position":24,"is_corresponding":false},{"id":105287,"name":"Emilie K. Grasset","orcid":"0000-0002-9592-1640","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-18T21:06:31.136481Z","pmid":"32737068","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}