{"doi":"10.1126/science.ady6443","title":"Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy","abstract":"Hypertrophic cardiomyopathy (HCM), a genetic heart disease defined by unexplained cardiac wall thickening, is a leading cause of sudden death worldwide. However, the three-dimensional organization of cardiac tissue underlying left ventricular hypertrophy remains poorly understood. We developed CaMVIA-3D, a deep-learning volumetric imaging and analysis pipeline to characterize cardiac microarchitecture. Analysis of tissues from HCM hearts revealed genotype-specific differences in cardiomyocyte volume, morphology, and extracellular volume, with pathogenic variants exhibiting greater concentric cellular hypertrophy and disarray and variant-negative cases showing predominant fibrosis. Longitudinal profiling of a pig HCM model revealed early-onset fibrosis preceding cardiomyocyte hypertrophy. Integrating transcriptomic and morphologic changes, we identified genes associated with cellular and extracellular remodeling. These findings define genotype-specific microstructural differences in HCM, offering insights to improve diagnostics and targeted therapies.","journal":"Science","year":2026,"id":542,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0578,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2026-01-15","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":5567,"name":"Martin Beyer","orcid":"0000-0003-0925-7067","position":1,"is_corresponding":false},{"id":5568,"name":"Kemar J. Brown","orcid":"0000-0002-2184-4654","position":2,"is_corresponding":false},{"id":5569,"name":"Alexander J. Bansbach","orcid":"0009-0008-8893-7629","position":3,"is_corresponding":false},{"id":5570,"name":"Joshua M. Gorham","orcid":"0000-0001-5969-4690","position":4,"is_corresponding":false},{"id":5571,"name":"Barbara McDonough","orcid":"0000-0002-4257-8623","position":5,"is_corresponding":false},{"id":5572,"name":"Huachen Chen","orcid":"0000-0003-3542-0884","position":6,"is_corresponding":false},{"id":5573,"name":"Mobin Khoramjoo","orcid":null,"position":7,"is_corresponding":false},{"id":5574,"name":"Anran Zhang","orcid":"0000-0002-9286-453X","position":8,"is_corresponding":false},{"id":5575,"name":"Brian Bishop","orcid":"0009-0009-3849-1216","position":9,"is_corresponding":false},{"id":5576,"name":"Ferhaan Ahmad","orcid":"0000-0003-2877-4641","position":10,"is_corresponding":false},{"id":5577,"name":"Carlos del Rio","orcid":"0000-0002-9761-7888","position":11,"is_corresponding":false},{"id":5578,"name":"Ching-Pin Chang","orcid":null,"position":12,"is_corresponding":false},{"id":5579,"name":"David M. Ryba","orcid":"0009-0007-3210-767X","position":13,"is_corresponding":false},{"id":5580,"name":"Sharlene M. Day","orcid":"0000-0001-9802-7188","position":14,"is_corresponding":false},{"id":5581,"name":"Diane Fatkin","orcid":"0000-0002-9010-9856","position":15,"is_corresponding":false},{"id":5582,"name":"Gavin Y. Oudit","orcid":"0000-0002-9154-9028","position":16,"is_corresponding":false},{"id":5583,"name":"Christine E. Seidman","orcid":"0000-0001-6380-1209","position":17,"is_corresponding":false},{"id":5584,"name":"Jonathan G. Seidman","orcid":"0000-0002-9082-3566","position":18,"is_corresponding":false},{"id":5585,"name":"K A Brown","orcid":null,"position":19,"is_corresponding":false},{"id":5586,"name":"Alexander Bansbach","orcid":null,"position":20,"is_corresponding":false},{"id":5587,"name":"Brian L. Bishop","orcid":"0000-0002-8098-119X","position":21,"is_corresponding":false},{"id":5588,"name":"SC Day","orcid":null,"position":22,"is_corresponding":false},{"id":5589,"name":"D Fatkin","orcid":null,"position":23,"is_corresponding":false},{"id":5590,"name":"J G Seidman","orcid":null,"position":24,"is_corresponding":false},{"id":5566,"name":"Eric Q. Wei","orcid":"0000-0001-5948-0174","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}