{"doi":"10.1126/science.ady5362","title":"Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity","abstract":"<jats:p>\n                    Conventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8\n                    <jats:sup>+</jats:sup>\n                    T cells. How tumor antigens are processed to activate CD8\n                    <jats:sup>+</jats:sup>\n                    T cell immunity is not well understood. In this work, we show that Ms4a7 is up-regulated in cDC1s after tumor antigen uptake or exposure to exogenous stimuli and is required for their cross-priming ability. Although\n                    <jats:italic toggle=\"yes\">Ms4a7</jats:italic>\n                    <jats:sup>−/−</jats:sup>\n                    mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8\n                    <jats:sup>+</jats:sup>\n                    T cells following infection or tumor development. In human cancers,\n                    <jats:italic toggle=\"yes\">MS4A7</jats:italic>\n                    was expressed in a subset of cDC1s, preferentially enriched in dLNs, and correlated with patient survival. Our findings suggest a critical role for Ms4a7 in cDC1-mediated cross-presentation and antitumor CD8\n                    <jats:sup>+</jats:sup>\n                    T cell responses.\n                  </jats:p>","journal":"Science","year":2025,"id":615523,"datarank":0.3596842909197557,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.0,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1549372,"name":"Bowen Yuan","orcid":"0009-0009-0424-6378","position":1,"is_corresponding":false},{"id":911142,"name":"Xiaohong Zhao","orcid":"0000-0003-3270-9076","position":2,"is_corresponding":false},{"id":1033184,"name":"Tian Xie","orcid":"0000-0002-5445-664X","position":3,"is_corresponding":false},{"id":302466,"name":"Ruifeng Li","orcid":"0000-0003-3498-1567","position":4,"is_corresponding":false},{"id":326350,"name":"Peng Wei","orcid":"0000-0003-1107-6732","position":5,"is_corresponding":false},{"id":1461468,"name":"Qinli Sun","orcid":"0000-0002-1220-3388","position":6,"is_corresponding":false},{"id":1586555,"name":"Wenbo Hu","orcid":null,"position":7,"is_corresponding":false},{"id":1586557,"name":"Birui Pan","orcid":null,"position":8,"is_corresponding":false},{"id":420445,"name":"Yongzhen Chen","orcid":"0000-0002-5998-7132","position":9,"is_corresponding":false},{"id":274498,"name":"Kun Wei","orcid":"0009-0007-1583-0196","position":10,"is_corresponding":false},{"id":1484883,"name":"Zixuan Zhao","orcid":"0000-0001-7460-0074","position":11,"is_corresponding":false},{"id":721981,"name":"Lei Yuan","orcid":"0009-0003-3309-1746","position":12,"is_corresponding":false},{"id":1586561,"name":"Xuan Zhong","orcid":"0009-0009-9096-4295","position":13,"is_corresponding":false},{"id":451338,"name":"Xue Bai","orcid":"0000-0002-5973-0353","position":14,"is_corresponding":false},{"id":449773,"name":"Qiuyan Lan","orcid":"0000-0003-0984-6259","position":15,"is_corresponding":false},{"id":240498,"name":"Lei Qin","orcid":"0000-0003-1407-4433","position":16,"is_corresponding":false},{"id":1586568,"name":"Ling Ni","orcid":"0000-0003-1569-882X","position":17,"is_corresponding":false},{"id":278638,"name":"Chen Dong","orcid":"0000-0002-0084-9130","position":18,"is_corresponding":false},{"id":259296,"name":"Bowen Xie","orcid":"0000-0003-2476-0357","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity","abstract":"<jats:p>\n                    Conventional type 1 dendritic cells (cDC1s) capture antigens in peripheral tissues and migrate to draining lymph nodes (dLNs) to prime antigen-specific CD8\n                    <jats:sup>+</jats:sup>\n                    T cells. How tumor antigens are processed to activate CD8\n                    <jats:sup>+</jats:sup>\n                    T cell immunity is not well understood. In this work, we show that Ms4a7 is up-regulated in cDC1s after tumor antigen uptake or exposure to exogenous stimuli and is required for their cross-priming ability. Although\n                    <jats:italic toggle=\"yes\">Ms4a7</jats:italic>\n                    <jats:sup>−/−</jats:sup>\n                    mice showed normal cDC1 development and turnover, they failed to prime antigen-specific CD8\n                    <jats:sup>+</jats:sup>\n                    T cells following infection or tumor development. In human cancers,\n                    <jats:italic toggle=\"yes\">MS4A7</jats:italic>\n                    was expressed in a subset of cDC1s, preferentially enriched in dLNs, and correlated with patient survival. Our findings suggest a critical role for Ms4a7 in cDC1-mediated cross-presentation and antitumor CD8\n                    <jats:sup>+</jats:sup>\n                    T cell responses.\n                  </jats:p>","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"41231994","pmcid":null,"openalex_id":"https://openalex.org/W4416179456","authors":[],"funders":[],"total_grants":0,"fwci":4.0206,"citation_percentile":0.9476793,"influential_citations":0,"citation_trend":[{"year":2026,"count":10}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.ady5362","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.ady5362","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/41231994","host_type":"repository"}],"fields_of_study":["Immunotherapy and Immune Responses","Cell Adhesion Molecules Research","Melanoma and MAPK Pathways","Animals","Humans","Mice","Antigens, Neoplasm","CD8-Positive T-Lymphocytes","Cell Line, Tumor","Cross-Priming","Dendritic Cells","Lymph Nodes","Mice, Inbred C57BL","Mice, Knockout","Neoplasms","Up-Regulation","Membrane Proteins","Antigens, CD20"],"mesh_terms":["Animals","Antigens, Neoplasm","Dendritic Cells","Humans","Lymph Nodes","Membrane Proteins","Mice, Inbred C57BL","Neoplasms","Up-Regulation","Mice, Knockout","CD8-Positive T-Lymphocytes","Antigens, CD20","Cross-Priming","Cell Line, Tumor","Mice"],"keywords":["Antigen","Immunity","Cellular immunity","Tumor cells","Tumor antigen","T cell","Immune system","T lymphocyte"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-02T20:15:37.100038Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}