{"doi":"10.1126/science.ady2969","title":"Trifluoromethylation of alkyl electrophiles with <sup>11</sup> C- or <sup>18</sup> F-labeled fluoroform for PET applications","abstract":"Continued development of positron emission tomography (PET) tracers is essential for advancing molecular imaging in biomedical research and clinical diagnostics. A long-standing limitation in radiochemistry for PET imaging has been the lack of general methods for radiolabeling trifluoromethyl (CF 3 ) groups at C(sp 3 ) sites, despite their growing prevalence in bioactive molecules and radiopharmaceuticals. Here, we present a general approach for late-stage installation of either a [ 18 F]CF 3 or [ 11 C]CF 3 group at a C(sp 3 ) site. This method leverages unusual copper-mediated radiotrifluoromethylation of alkyl halides and alkyl carboxylic acids by halogen atom transfer and photoredox catalysis, respectively. More than 50 complex molecules and pharmaceutical agents were efficiently labeled with fluorine-18 ( 18 F) or carbon-11 ( 11 C). Two long-sought-after radioligands, [ 18 F]SL25.1188 and [ 18 F]PS13, were synthesized, providing longer-lived 18 F analogs of their 11 C counterparts with great promise for human PET imaging.","journal":"Science","year":2025,"id":522455,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9536,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1394488,"name":"Paul M. DeMent","orcid":null,"position":1,"is_corresponding":false},{"id":420082,"name":"Susovan Jana","orcid":"0000-0001-9910-347X","position":2,"is_corresponding":false},{"id":353942,"name":"Jinsoo Hong","orcid":"0000-0002-0450-6258","position":3,"is_corresponding":false},{"id":342697,"name":"Victor W. Pike","orcid":"0000-0001-9032-2553","position":4,"is_corresponding":false},{"id":1393991,"name":"Wei Liu","orcid":"0000-0001-6249-3179","position":5,"is_corresponding":false},{"id":1393990,"name":"C.-Y. Wang","orcid":"0009-0009-0488-1670","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-19T02:49:54.058858Z","pmid":"41411425","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}