{"doi":"10.1126/science.adx0659","title":"Comparative analysis of human and mouse ovaries across age","abstract":"The mouse is a tractable model for human ovarian biology; however, its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compared ovaries between species using three-dimensional imaging, single-cell transcriptomics, and functional studies. In mice, we mapped declining follicle numbers and oocyte competence during aging; in human ovaries, we identified cortical follicle pockets and decreases in density. Oocytes had species-specific gene expression patterns during growth that converged toward maturity. Age-related transcriptional changes were greater in oocytes than in granulosa cells across species, although mature oocytes change more in humans. We identified ovarian sympathetic nerves and glia; axon density increased in aged ovaries and, when ablated in mice, perturbed folliculogenesis. This comparative atlas defines shared and species-specific hallmarks of ovarian biology.","journal":"Science","year":2025,"id":509859,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8629,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":620085,"name":"Mariko H. Foecke","orcid":"0000-0002-9205-940X","position":1,"is_corresponding":false},{"id":239633,"name":"Ryan M. Samuel","orcid":"0000-0002-9473-1378","position":2,"is_corresponding":false},{"id":305903,"name":"Bikem Soygur","orcid":"0000-0002-2749-9871","position":3,"is_corresponding":false},{"id":74074,"name":"Angela M. Detweiler","orcid":"0000-0001-7026-5467","position":4,"is_corresponding":false},{"id":681690,"name":"Tara I. McIntyre","orcid":"0000-0001-6670-9977","position":5,"is_corresponding":false},{"id":110075,"name":"Leah C. Dorman","orcid":"0000-0002-5511-887X","position":6,"is_corresponding":false},{"id":556164,"name":"Michael Borja","orcid":"0009-0006-4527-3370","position":7,"is_corresponding":false},{"id":1225071,"name":"Amy Laird","orcid":"0000-0002-7592-9901","position":8,"is_corresponding":false},{"id":1365890,"name":"Ritwicq Arjyal","orcid":null,"position":9,"is_corresponding":false},{"id":1365058,"name":"Juan Du","orcid":"0000-0003-4701-3573","position":10,"is_corresponding":false},{"id":73995,"name":"James M. Gardner","orcid":"0000-0003-3470-9520","position":11,"is_corresponding":false},{"id":11050,"name":"Norma Neff","orcid":"0000-0001-7141-5420","position":12,"is_corresponding":false},{"id":239649,"name":"Faranak Fattahi","orcid":"0000-0002-9473-8596","position":13,"is_corresponding":false},{"id":305906,"name":"Diana J. Laird","orcid":"0000-0002-4930-0560","position":14,"is_corresponding":false},{"id":286185,"name":"Eliza A. Gaylord","orcid":"0000-0003-2986-4630","position":0,"is_corresponding":true}],"reference_count":148,"raw_metadata":null,"created_at":"2026-07-19T02:47:30.942539Z","pmid":"41066539","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}