{"doi":"10.1126/science.adr6896","title":"Affinity maturation of antibody responses is mediated by differential plasma cell proliferation","abstract":"Increased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, is selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown. We found that PC precursors (prePCs) expressing high-affinity antibodies received higher levels of T follicular helper cell (T FH cell)–derived help and divided at higher rates compared with their lower-affinity counterparts once they left the germinal center. Our findings indicate that differential cell division by selected prePCs accounts for how diverse precursors develop into a PC compartment that mediates serological affinity maturation.","journal":"Science","year":2024,"id":419179,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1208541,"name":"Lachlan P. Deimel","orcid":"0000-0003-3803-871X","position":1,"is_corresponding":false},{"id":857974,"name":"Pengcheng Zhou","orcid":"0000-0002-7736-2902","position":2,"is_corresponding":false},{"id":235902,"name":"Mohamed ElTanbouly","orcid":"0000-0001-7985-3839","position":3,"is_corresponding":false},{"id":539599,"name":"Julia Merkenschlager","orcid":"0000-0001-6726-7939","position":4,"is_corresponding":false},{"id":104721,"name":"Víctor Ramos","orcid":"0000-0001-7353-3420","position":5,"is_corresponding":false},{"id":1049752,"name":"Gabriela S. Silva Santos","orcid":"0000-0002-7482-7380","position":6,"is_corresponding":false},{"id":104711,"name":"Thomas Hägglöf","orcid":"0000-0002-7751-0928","position":7,"is_corresponding":false},{"id":301421,"name":"Christian T. Mayer","orcid":"0000-0002-0256-9650","position":8,"is_corresponding":false},{"id":424866,"name":"Brianna Hernandez","orcid":"0000-0002-4044-316X","position":9,"is_corresponding":false},{"id":104709,"name":"Anna Gazumyan","orcid":"0000-0002-5976-9717","position":10,"is_corresponding":false},{"id":104187,"name":"Michel C. Nussenzweig","orcid":"0000-0003-0592-8564","position":11,"is_corresponding":false},{"id":1036251,"name":"Andrew J. MacLean","orcid":"0009-0008-8378-4141","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:57:14.586331Z","pmid":"39700316","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}