{"doi":"10.1126/science.adq3519","title":"A solution to the anti-Bredt olefin synthesis problem","abstract":"The π-bonds in unsaturated organic molecules are typically associated with having well-defined geometries that are conserved across diverse structural contexts. Nonetheless, these geometries can be distorted, leading to heightened reactivity of the π-bond. Although π-bond-containing compounds with bent geometries are well utilized in synthetic chemistry, the corresponding leveraging of π-bond-containing compounds that display twisting or pyramidalization remains underdeveloped. We report a study of perhaps the most notorious class of geometrically distorted molecules that contain π-bonds: anti-Bredt olefins (ABOs). ABOs have been known since 1924, and conventional wisdom maintains that ABOs are difficult or impossible to access. We provide a solution to this long-standing problem. Our study also highlights the strategic manipulation of compounds that display considerable distortion arising from the presence of geometrically constrained π-bonds.","journal":"Science","year":2024,"id":419528,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9494,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1210239,"name":"Zach G. Walters","orcid":null,"position":1,"is_corresponding":false},{"id":1209487,"name":"Sarah A. French","orcid":"0000-0003-2089-3857","position":2,"is_corresponding":false},{"id":1209488,"name":"Allison M. Clark","orcid":"0000-0003-2956-1787","position":3,"is_corresponding":false},{"id":1057198,"name":"Jiaming Ding","orcid":"0000-0003-4284-5274","position":4,"is_corresponding":false},{"id":1033123,"name":"Andrew V. Kelleghan","orcid":"0000-0002-9774-2873","position":5,"is_corresponding":false},{"id":292448,"name":"K. N. Houk","orcid":"0000-0002-8387-5261","position":6,"is_corresponding":false},{"id":685230,"name":"Neil K. Garg","orcid":"0000-0002-7793-2629","position":7,"is_corresponding":false},{"id":1126047,"name":"Luca McDermott","orcid":"0000-0002-9899-2145","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T01:57:19.937291Z","pmid":"39480919","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}