{"doi":"10.1126/science.adp5831","title":"Cross-species implementation of an innate courtship behavior by manipulation of the sex-determinant gene","abstract":"<jats:p>\n            In accepting a courting male,\n            <jats:italic toggle=\"yes\">Drosophila subobscura</jats:italic>\n            females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in\n            <jats:italic toggle=\"yes\">D. melanogaster</jats:italic>\n            . By clonal activation of neurons expressing the male-determinant FruM, we identified insulin-like peptide–producing cells (IPCs) and their putative postsynaptic targets, proboscis-innervating motoneurons, as those critical for gift giving. We demonstrate that loss of FruM from\n            <jats:italic toggle=\"yes\">D. subobscura</jats:italic>\n            IPCs abrogates neurite extension and gift giving, whereas FruM overexpression in their\n            <jats:italic toggle=\"yes\">D. melanogaster</jats:italic>\n            counterparts induces overgrowth of neurites that harbor functional synapses, culminating in increased regurgitation. We suggest that the acquisition of FruM expression by IPCs was a key event occurring in an ancestral\n            <jats:italic toggle=\"yes\">D. subobscura</jats:italic>\n            that conferred a latent capability to perform nuptial gift giving.\n          </jats:p>","journal":"Science","year":2025,"id":618107,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1594331,"name":"Yusuke Hara","orcid":"0000-0002-8703-0362","position":1,"is_corresponding":false},{"id":1594332,"name":"Kosei Sato","orcid":"0000-0002-4463-1440","position":2,"is_corresponding":false},{"id":1594334,"name":"Soh Kohatsu","orcid":null,"position":3,"is_corresponding":false},{"id":1594335,"name":"Hinata Murakami","orcid":null,"position":4,"is_corresponding":false},{"id":1594336,"name":"Tomohiro Higuchi","orcid":null,"position":5,"is_corresponding":false},{"id":1594337,"name":"Takeshi Awasaki","orcid":"0000-0003-2662-6389","position":6,"is_corresponding":false},{"id":259044,"name":"Shu Kondo","orcid":"0000-0002-4625-8379","position":7,"is_corresponding":false},{"id":14518,"name":"Atsushi Toyoda","orcid":"0000-0002-0728-7548","position":8,"is_corresponding":false},{"id":1299019,"name":"Azusa Kamikouchi","orcid":"0000-0003-1552-6892","position":9,"is_corresponding":false},{"id":1545988,"name":"Daisuke Yamamoto","orcid":"0000-0002-4623-0106","position":10,"is_corresponding":false},{"id":1594330,"name":"Ryoya Tanaka","orcid":"0000-0002-6047-6030","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cross-species implementation of an innate courtship behavior by manipulation of the sex-determinant gene","abstract":"<jats:p>\n            In accepting a courting male,\n            <jats:italic toggle=\"yes\">Drosophila subobscura</jats:italic>\n            females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in\n            <jats:italic toggle=\"yes\">D. melanogaster</jats:italic>\n            . By clonal activation of neurons expressing the male-determinant FruM, we identified insulin-like peptide–producing cells (IPCs) and their putative postsynaptic targets, proboscis-innervating motoneurons, as those critical for gift giving. We demonstrate that loss of FruM from\n            <jats:italic toggle=\"yes\">D. subobscura</jats:italic>\n            IPCs abrogates neurite extension and gift giving, whereas FruM overexpression in their\n            <jats:italic toggle=\"yes\">D. melanogaster</jats:italic>\n            counterparts induces overgrowth of neurites that harbor functional synapses, culminating in increased regurgitation. We suggest that the acquisition of FruM expression by IPCs was a key event occurring in an ancestral\n            <jats:italic toggle=\"yes\">D. subobscura</jats:italic>\n            that conferred a latent capability to perform nuptial gift giving.\n          </jats:p>","is_dataset_classified":null,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40811529","pmcid":null,"openalex_id":"https://openalex.org/W4413140930","authors":[],"funders":[],"total_grants":0,"fwci":4.9311,"citation_percentile":0.96256625,"influential_citations":0,"citation_trend":[{"year":2025,"count":5},{"year":2026,"count":5}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.science.org/doi/pdf/10.1126/science.adp5831","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.adp5831","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40811529","host_type":"repository"}],"fields_of_study":["Neurobiology and Insect Physiology Research","Animal Behavior and Reproduction","Invertebrate Immune Response Mechanisms","Animals","Female","Male","Courtship","Drosophila","Drosophila melanogaster","Drosophila Proteins","Motor Neurons","Nerve Tissue Proteins","Sexual Behavior, Animal","Synapses","Transcription Factors"],"mesh_terms":["Animals","Courtship","Drosophila","Drosophila melanogaster","Female","Male","Motor Neurons","Nerve Tissue Proteins","Sexual Behavior, Animal","Synapses","Transcription Factors","Drosophila Proteins"],"keywords":["Drosophila melanogaster","Biology","Courtship","Melanogaster","Proboscis","Cell biology","Gene","Genetics","Zoology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:29:22.475771Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}