{"doi":"10.1126/science.adp1562","title":"A long noncoding eRNA forms R-loops to shape emotional experience–induced behavioral adaptation","abstract":"Emotional experiences often evoke neural plasticity that supports adaptive changes in behavior, including maladaptive plasticity associated with mood and substance use disorders. These adaptations are supported in part by experience-dependent activation of immediate-early response genes, such as Npas4 (neuronal PAS domain protein 4). Here we show that a conserved long noncoding enhancer RNA (lnc-eRNA), transcribed from an activity-sensitive enhancer, produces DNA:RNA hybrid R-loop structures that support three-dimensional chromatin looping between enhancer and proximal promoter and rapid Npas4 gene induction. Furthermore, in mouse models, Npas4 lnc-eRNA and its R-loop are required for the development of behavioral adaptations produced by chronic psychosocial stress or cocaine exposure, revealing a potential role for this regulatory mechanism in the transmission of emotional experiences.","journal":"Science","year":2024,"id":420533,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9492,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":820212,"name":"Rebecca G Cornbrooks","orcid":null,"position":1,"is_corresponding":false},{"id":1212665,"name":"Kosuke Magami","orcid":null,"position":2,"is_corresponding":false},{"id":1209593,"name":"Alain Greige","orcid":"0009-0007-0811-8416","position":3,"is_corresponding":false},{"id":830743,"name":"Kirsten K. Snyder","orcid":null,"position":4,"is_corresponding":false},{"id":1211963,"name":"Daniel J. Wood","orcid":"0000-0003-1874-7738","position":5,"is_corresponding":false},{"id":1212666,"name":"Mary Claire Herrington","orcid":null,"position":6,"is_corresponding":false},{"id":1212667,"name":"Philip Mace","orcid":null,"position":7,"is_corresponding":false},{"id":1211964,"name":"Kyle Blidy","orcid":"0000-0001-6997-7221","position":8,"is_corresponding":false},{"id":460025,"name":"Nobuya Koike","orcid":null,"position":9,"is_corresponding":false},{"id":311328,"name":"Stefano Berto","orcid":"0000-0001-9028-9458","position":10,"is_corresponding":false},{"id":287641,"name":"Christopher W. Cowan","orcid":"0000-0001-5472-3296","position":11,"is_corresponding":false},{"id":819868,"name":"Makoto Taniguchi","orcid":"0000-0001-6356-2463","position":12,"is_corresponding":false},{"id":819867,"name":"Rose Marie Akiki","orcid":"0000-0001-8141-5344","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:57:31.041511Z","pmid":"39666799","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}