{"doi":"10.1126/science.adm7607","title":"Homeocurvature adaptation of phospholipids to pressure in deep-sea invertebrates","abstract":"Hydrostatic pressure increases with depth in the ocean, but little is known about the molecular bases of biological pressure tolerance. We describe a mode of pressure adaptation in comb jellies (ctenophores) that also constrains these animals’ depth range. Structural analysis of deep-sea ctenophore lipids shows that they form a nonbilayer phase at pressures under which the phase is not typically stable. Lipidomics and all-atom simulations identified phospholipids with strong negative spontaneous curvature, including plasmalogens, as a hallmark of deep-adapted membranes that causes this phase behavior. Synthesis of plasmalogens enhanced pressure tolerance in Escherichia coli , whereas low-curvature lipids had the opposite effect. Imaging of ctenophore tissues indicated that the disintegration of deep-sea animals when decompressed could be driven by a phase transition in their phospholipid membranes.","journal":"Science","year":2024,"id":417656,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1025473,"name":"Daniel Milshteyn","orcid":"0000-0002-1883-9897","position":1,"is_corresponding":false},{"id":1203986,"name":"S. Urbano","orcid":"0009-0003-2850-2184","position":2,"is_corresponding":false},{"id":1203987,"name":"Miguel A. Pedraza-Joya","orcid":"0009-0008-4008-8701","position":3,"is_corresponding":false},{"id":310452,"name":"Aaron M. Armando","orcid":"0009-0003-4598-7371","position":4,"is_corresponding":false},{"id":310453,"name":"Oswald Quehenberger","orcid":"0000-0001-8950-9169","position":5,"is_corresponding":false},{"id":532104,"name":"Alexander J. Sodt","orcid":"0000-0002-5570-8212","position":6,"is_corresponding":false},{"id":367466,"name":"Richard E. Gillilan","orcid":"0000-0002-7636-3188","position":7,"is_corresponding":false},{"id":108033,"name":"Edward A. Dennis","orcid":"0000-0003-3738-3140","position":8,"is_corresponding":false},{"id":363454,"name":"Edward Lyman","orcid":"0000-0003-4590-0363","position":9,"is_corresponding":false},{"id":3686,"name":"Steven H. D. Haddock","orcid":"0000-0001-9420-4482","position":10,"is_corresponding":false},{"id":1025474,"name":"Itay Budin","orcid":"0000-0001-9706-4294","position":11,"is_corresponding":false},{"id":897641,"name":"Jacob R. Winnikoff","orcid":"0000-0002-0197-3205","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T01:56:56.807779Z","pmid":"38935710","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}