{"doi":"10.1126/science.adl0882","title":"The <i>MUC19</i> gene: An evolutionary history of recurrent introgression and natural selection","abstract":"We study the gene MUC19 , for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants for the Denisovan-like MUC19 haplotype at high frequencies in admixed American individuals and at highest frequency in 23 ancient Indigenous American individuals, all pre-dating population admixture with Europeans and Africans. We find that the Denisovan-like MUC19 haplotype is under positive selection and carries a higher copy number of a 30–base-pair variable number tandem repeat, and that copy numbers of this repeat are exceedingly high in admixed American populations. Finally, we find that some Neanderthals carry the Denisovan-like MUC19 haplotype, and that it was likely introgressed into modern human populations through Neanderthal introgression rather than Denisovan introgression.","journal":"Science","year":2025,"id":513540,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409113,"name":"David Peede","orcid":"0000-0002-4826-0464","position":1,"is_corresponding":false},{"id":1082684,"name":"Eli J. Kaufman","orcid":"0000-0001-8553-210X","position":2,"is_corresponding":false},{"id":1056734,"name":"Valeria Añorve-Garibay","orcid":null,"position":3,"is_corresponding":false},{"id":1090503,"name":"Elizabeth T. Chevy","orcid":"0000-0003-2279-6129","position":4,"is_corresponding":false},{"id":1056219,"name":"Viridiana Villa-Islas","orcid":"0000-0001-9218-561X","position":5,"is_corresponding":false},{"id":557974,"name":"Kelsey E. Witt","orcid":"0000-0002-3242-2123","position":6,"is_corresponding":false},{"id":1163850,"name":"Roberta Zeloni","orcid":null,"position":7,"is_corresponding":false},{"id":295058,"name":"Davide Marnetto","orcid":"0000-0001-9573-0601","position":8,"is_corresponding":false},{"id":19577,"name":"Priya Moorjani","orcid":"0000-0002-0947-5673","position":9,"is_corresponding":false},{"id":40402,"name":"Flora Jay","orcid":"0000-0001-5884-4730","position":10,"is_corresponding":false},{"id":345186,"name":"Paul N. Valdmanis","orcid":"0000-0001-8840-6969","position":11,"is_corresponding":false},{"id":247493,"name":"María C. Ávila‐Arcos","orcid":"0000-0003-1691-1696","position":12,"is_corresponding":false},{"id":334779,"name":"Emilia Huerta‐Sánchez","orcid":"0000-0002-1506-5494","position":13,"is_corresponding":false},{"id":816431,"name":"Fernando A. Villanea","orcid":"0000-0002-6661-0368","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T02:48:17.908238Z","pmid":"40839725","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}