{"doi":"10.1126/science.adg8835","title":"Handling fluorinated gases as solid reagents using metal-organic frameworks","abstract":"Fluorine is an increasingly common substituent in pharmaceuticals and agrochemicals because it improves the bioavailability and metabolic stability of organic molecules. Fluorinated gases represent intuitive building blocks for the late-stage installation of fluorinated groups, but they are generally overlooked because they require the use of specialized equipment. We report a general strategy for handling fluorinated gases as benchtop-stable solid reagents using metal-organic frameworks (MOFs). Gas-MOF reagents are prepared on gram-scale and used to facilitate fluorovinylation and fluoroalkylation reactions. Encapsulation of gas-MOF reagents within wax enables stable storage on the benchtop and controlled release into solution upon sonication, which represents a safer alternative to handling the gas directly. Furthermore, our approach enables high-throughput reaction development with these gases.","journal":"Science","year":2023,"id":319157,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":693831,"name":"Mary E. Zick","orcid":"0000-0002-3819-5347","position":1,"is_corresponding":false},{"id":1027815,"name":"Emily Stacy","orcid":"0009-0003-3353-2003","position":2,"is_corresponding":false},{"id":663538,"name":"Jaehwan Kim","orcid":"0000-0003-1311-4982","position":3,"is_corresponding":false},{"id":228302,"name":"Jung‐Hoon Lee","orcid":"0000-0002-2983-678X","position":4,"is_corresponding":false},{"id":1027816,"name":"Lida Aeindartehran","orcid":"0000-0001-7592-1363","position":5,"is_corresponding":false},{"id":934707,"name":"Tomče Runčevski","orcid":"0000-0003-0886-8464","position":6,"is_corresponding":false},{"id":228304,"name":"Phillip J. Milner","orcid":"0000-0002-2618-013X","position":7,"is_corresponding":false},{"id":1027814,"name":"Kaitlyn T. Keasler","orcid":"0000-0003-4805-9602","position":0,"is_corresponding":true}],"reference_count":113,"raw_metadata":null,"created_at":"2026-07-19T01:07:12.004111Z","pmid":"37769097","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}