{"doi":"10.1126/science.adg4725","title":"Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing","abstract":", the editosome, composed of RNA-editing substrate-binding complex (RESC) and RNA-editing catalytic complex (RECC), orchestrates guide RNA (gRNA)-programmed editing to recode cryptic mitochondrial transcripts into messenger RNAs (mRNAs). The mechanism of information transfer from gRNA to mRNA is unclear owing to a lack of high-resolution structures for these complexes. With cryo-electron microscopy and functional studies, we have captured gRNA-stabilizing RESC-A and gRNA-mRNA-binding RESC-B and RESC-C particles. RESC-A sequesters gRNA termini, thus promoting hairpin formation and blocking mRNA access. The conversion of RESC-A into RESC-B or -C unfolds gRNA and allows mRNA selection. The ensuing gRNA-mRNA duplex protrudes from RESC-B, likely exposing editing sites to RECC-catalyzed cleavage, uridine insertion or deletion, and ligation. Our work reveals a remodeling event facilitating gRNA-mRNA hybridization and assembly of a macromolecular substrate for the editosome's catalytic modality.","journal":"Science","year":2023,"id":328954,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.952,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1050982,"name":"Hong Wang","orcid":"0000-0002-5767-2882","position":1,"is_corresponding":false},{"id":690397,"name":"Xiaorun Li","orcid":"0000-0003-2100-7554","position":2,"is_corresponding":false},{"id":1050983,"name":"Fan Zhang","orcid":"0000-0002-2858-0698","position":3,"is_corresponding":false},{"id":906968,"name":"Jane K.J. Lee","orcid":"0000-0001-7735-7647","position":4,"is_corresponding":false},{"id":488794,"name":"Zihang Li","orcid":"0000-0002-4625-9283","position":5,"is_corresponding":false},{"id":289624,"name":"Clinton Yu","orcid":"0000-0002-2931-5474","position":6,"is_corresponding":false},{"id":906967,"name":"Jason J. Hu","orcid":"0000-0002-1103-2177","position":7,"is_corresponding":false},{"id":58772,"name":"Xiaojing Zhao","orcid":"0000-0002-4937-9088","position":8,"is_corresponding":false},{"id":447620,"name":"Takuma Suematsu","orcid":"0000-0003-1430-6580","position":9,"is_corresponding":false},{"id":544301,"name":"Ana L. Alvarez-Cabrera","orcid":"0000-0001-7186-9393","position":10,"is_corresponding":false},{"id":447621,"name":"Qiushi Liu","orcid":"0000-0003-1194-6080","position":11,"is_corresponding":false},{"id":273331,"name":"Liye Zhang","orcid":"0000-0003-2104-6828","position":12,"is_corresponding":false},{"id":289627,"name":"Lan Huang","orcid":"0000-0002-3140-4687","position":13,"is_corresponding":false},{"id":276052,"name":"Inna Aphasizheva","orcid":null,"position":14,"is_corresponding":false},{"id":276055,"name":"Ruslan Aphasizhev","orcid":null,"position":15,"is_corresponding":false},{"id":266761,"name":"Z. Hong Zhou","orcid":"0000-0002-8373-4717","position":16,"is_corresponding":false},{"id":323740,"name":"Shiheng Liu","orcid":"0000-0002-0561-1981","position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":null,"created_at":"2026-07-19T01:08:56.940647Z","pmid":"37410820","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}