{"doi":"10.1126/science.adg0934","title":"Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution","abstract":"Aging is characterized by a decline in tissue function, but the underlying changes at cellular resolution across the organism remain unclear. Here, we present the Aging Fly Cell Atlas, a single-nucleus transcriptomic map of the whole aging Drosophila . We characterized 163 distinct cell types and performed an in-depth analysis of changes in tissue cell composition, gene expression, and cell identities. We further developed aging clock models to predict fly age and show that ribosomal gene expression is a conserved predictive factor for age. Combining all aging features, we find distinctive cell type–specific aging patterns. This atlas provides a valuable resource for studying fundamental principles of aging in complex organisms.","journal":"Science","year":2023,"id":315932,"datarank":2.393527401001337,"base_score":4.836281906951478,"endowment":4.836281906951478,"self_citation_contribution":0.7254422860427218,"citation_network_contribution":1.6680851149586153,"self_endowment_contribution":0.7254422860427218,"citer_contribution":1.6680851149586153,"corpus_percentile":91.10389108068384,"corpus_rank":1151,"citation_count":125,"citer_count":100,"citers_with_citation_signal":86,"citers_with_endowment":86,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.8646,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":64648,"name":"Maria Brbić","orcid":"0000-0002-1120-1778","position":1,"is_corresponding":false},{"id":457513,"name":"Ye-Jin Park","orcid":"0000-0002-8066-4194","position":2,"is_corresponding":false},{"id":707254,"name":"Tyler Jackson","orcid":"0000-0003-2988-4340","position":3,"is_corresponding":false},{"id":811548,"name":"Jiaye Chen","orcid":"0000-0001-9654-1968","position":4,"is_corresponding":false},{"id":344993,"name":"Sai Saroja Kolluru","orcid":"0000-0002-3748-8519","position":5,"is_corresponding":false},{"id":551915,"name":"Yanyan Qi","orcid":"0000-0003-0537-1540","position":6,"is_corresponding":false},{"id":568633,"name":"Nadja Sandra Katheder","orcid":"0000-0003-0460-0938","position":7,"is_corresponding":false},{"id":832286,"name":"Xiaoyu Cai","orcid":"0000-0002-8510-2967","position":8,"is_corresponding":false},{"id":348469,"name":"Seungjae Lee","orcid":"0000-0001-5626-9656","position":9,"is_corresponding":false},{"id":237473,"name":"Yen‐Chung Chen","orcid":"0000-0002-8529-1251","position":10,"is_corresponding":false},{"id":977455,"name":"Niccole L. Auld","orcid":"0000-0001-5711-9430","position":11,"is_corresponding":false},{"id":465118,"name":"Chung‐Yi Liang","orcid":"0000-0003-3352-775X","position":12,"is_corresponding":false},{"id":986743,"name":"Sophia H. Ding","orcid":"0009-0006-7546-5197","position":13,"is_corresponding":false},{"id":986744,"name":"Doug Welsch","orcid":"0000-0002-3873-9586","position":14,"is_corresponding":false},{"id":986745,"name":"Samuel D’Souza","orcid":"0009-0003-2607-3742","position":15,"is_corresponding":false},{"id":49003,"name":"Angela Oliveira Pisco","orcid":"0000-0003-0142-2355","position":16,"is_corresponding":false},{"id":73982,"name":"Robert C. Jones","orcid":"0000-0001-7235-9854","position":17,"is_corresponding":false},{"id":16634,"name":"Jure Leskovec","orcid":"0000-0002-5411-923X","position":18,"is_corresponding":false},{"id":182940,"name":"Eric C Lai","orcid":"0000-0002-8432-5851","position":19,"is_corresponding":false},{"id":20909,"name":"Hugo J. Bellen","orcid":"0000-0001-5992-5989","position":20,"is_corresponding":false},{"id":242246,"name":"Liqun Luo","orcid":"0000-0001-5467-9264","position":21,"is_corresponding":false},{"id":319617,"name":"Heinrich Jasper","orcid":"0000-0002-6014-4343","position":22,"is_corresponding":false},{"id":11049,"name":"Stephen R. Quake","orcid":"0000-0002-1613-0809","position":23,"is_corresponding":false},{"id":242235,"name":"Hongjie Li","orcid":"0000-0002-7332-7122","position":24,"is_corresponding":false},{"id":551913,"name":"Tzu‐Chiao Lu","orcid":"0000-0001-9942-2307","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:06:32.274501Z","pmid":"37319212","pmcid":"PMC10829769","fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}