{"doi":"10.1126/science.adf1323","title":"Taxon-specific, phased siRNAs underlie a speciation locus in monkeyflowers","abstract":"Taxon-specific small RNA loci are widespread in eukaryotic genomes, yet their role in lineage-specific adaptation, phenotypic diversification, and speciation is poorly understood. Here, we report that a speciation locus in monkeyflowers ( Mimulus ), YELLOW UPPER ( YUP ), contains an inverted repeat region that produces small interfering RNAs (siRNAs) in a phased pattern. Although the inverted repeat is derived from a partial duplication of a protein-coding gene that is not involved in flower pigmentation, one of the siRNAs targets and represses a master regulator of floral carotenoid pigmentation. YUP emerged with two protein-coding genes that control other aspects of flower coloration as a “superlocus” in a subclade of Mimulus and has contributed to subsequent phenotypic diversification and pollinator-mediated speciation in the descendant species.","journal":"Science","year":2023,"id":316237,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":110,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1019655,"name":"Wenjie Chen","orcid":"0000-0003-0641-1815","position":1,"is_corresponding":false},{"id":618222,"name":"Amy M. LaFountain","orcid":"0000-0003-0583-2044","position":2,"is_corresponding":false},{"id":1019656,"name":"Yuanlong Liu","orcid":"0000-0003-2907-9069","position":3,"is_corresponding":false},{"id":262743,"name":"Foen Peng","orcid":"0000-0001-5549-7753","position":4,"is_corresponding":false},{"id":30988,"name":"Rui Xia","orcid":"0000-0003-2409-1181","position":5,"is_corresponding":false},{"id":265163,"name":"H. D. Bradshaw","orcid":null,"position":6,"is_corresponding":false},{"id":262745,"name":"Yao‐Wu Yuan","orcid":"0000-0003-1376-0028","position":7,"is_corresponding":false},{"id":1019654,"name":"Mei Liang","orcid":"0000-0002-4877-2443","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:06:38.213358Z","pmid":"36758083","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}