{"doi":"10.1126/science.add7034","title":"Probiotic-guided CAR-T cells for solid tumor targeting","abstract":"A major challenge facing tumor-antigen targeting therapies such as chimeric antigen receptor (CAR)-T cells is the identification of suitable targets that are specifically and uniformly expressed on heterogeneous solid tumors. By contrast, certain species of bacteria selectively colonize immune-privileged tumor cores and can be engineered as antigen-independent platforms for therapeutic delivery. To bridge these approaches, we developed a platform of probiotic-guided CAR-T cells (ProCARs), in which tumor-colonizing probiotics release synthetic targets that label tumor tissue for CAR-mediated lysis in situ. This system demonstrated CAR-T cell activation and antigen-agnostic cell lysis that was safe and effective in multiple xenograft and syngeneic models of human and mouse cancers. We further engineered multifunctional probiotics that co-release chemokines to enhance CAR-T cell recruitment and therapeutic response.","journal":"Science","year":2023,"id":315017,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":252,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":806521,"name":"Candice R. Gurbatri","orcid":"0000-0002-1464-7089","position":1,"is_corresponding":false},{"id":828769,"name":"Fangda Li","orcid":"0000-0002-4697-3989","position":2,"is_corresponding":false},{"id":1015644,"name":"Ana Vardoshvili","orcid":null,"position":3,"is_corresponding":false},{"id":806523,"name":"Courtney Coker","orcid":"0000-0002-8779-133X","position":4,"is_corresponding":false},{"id":827743,"name":"Jongwon Im","orcid":"0000-0002-3660-2770","position":5,"is_corresponding":false},{"id":1014797,"name":"Edward R. Ballister","orcid":"0000-0002-4478-2513","position":6,"is_corresponding":false},{"id":1014798,"name":"Mathieu Rouanne","orcid":"0000-0003-2970-4821","position":7,"is_corresponding":false},{"id":617613,"name":"Thomas Savage","orcid":"0000-0002-6618-2973","position":8,"is_corresponding":false},{"id":1014799,"name":"Kenia de los Santos-Alexis","orcid":"0000-0002-3628-9796","position":9,"is_corresponding":false},{"id":806522,"name":"Andrew Redenti","orcid":"0009-0001-3802-4927","position":10,"is_corresponding":false},{"id":1014800,"name":"Leonie Brockmann","orcid":"0000-0002-7789-7616","position":11,"is_corresponding":false},{"id":1014801,"name":"Meghna Komaranchath","orcid":"0009-0001-0329-7204","position":12,"is_corresponding":false},{"id":617615,"name":"Nicholas Arpaia","orcid":"0000-0002-0657-0528","position":13,"is_corresponding":false},{"id":584126,"name":"Tal Danino","orcid":"0000-0003-2713-7659","position":14,"is_corresponding":false},{"id":806520,"name":"Rosa L. Vincent","orcid":"0000-0003-0742-8977","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:06:02.898877Z","pmid":"37824640","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}