{"doi":"10.1126/science.add3067","title":"Spatially resolved single-cell translatomics at molecular resolution","abstract":"The precise control of messenger RNA (mRNA) translation is a crucial step in posttranscriptional gene regulation of cellular physiology. However, it remains a challenge to systematically study mRNA translation at the transcriptomic scale with spatial and single-cell resolution. Here, we report the development of ribosome-bound mRNA mapping (RIBOmap), a highly multiplexed three-dimensional in situ profiling method to detect cellular translatome. RIBOmap profiling of 981 genes in HeLa cells revealed cell cycle-dependent translational control and colocalized translation of functional gene modules. We mapped 5413 genes in mouse brain tissues, yielding spatially resolved single-cell translatomic profiles for 119,173 cells and revealing cell type-specific and brain region-specific translational regulation, including translation remodeling during oligodendrocyte maturation. Our method detected widespread patterns of localized translation in neuronal and glial cells in intact brain tissue networks.","journal":"Science","year":2023,"id":315266,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":190,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":640067,"name":"Jiahao Huang","orcid":"0000-0002-6349-9799","position":1,"is_corresponding":false},{"id":640068,"name":"Jingyi Ren","orcid":"0000-0001-9482-290X","position":2,"is_corresponding":false},{"id":1016244,"name":"Connie Kangni Wang","orcid":"0000-0002-9616-5154","position":3,"is_corresponding":false},{"id":89408,"name":"Zefang Tang","orcid":"0000-0002-5264-9560","position":4,"is_corresponding":false},{"id":227985,"name":"Haowen Zhou","orcid":"0000-0001-9678-1865","position":5,"is_corresponding":false},{"id":984570,"name":"Yiming Zhou","orcid":"0000-0002-8365-0396","position":6,"is_corresponding":false},{"id":87792,"name":"Hailing Shi","orcid":"0000-0001-7355-378X","position":7,"is_corresponding":false},{"id":640072,"name":"Abhishek Aditham","orcid":"0000-0003-3203-4574","position":8,"is_corresponding":false},{"id":984571,"name":"Xin Sui","orcid":"0000-0002-7286-9448","position":9,"is_corresponding":false},{"id":1016245,"name":"Hongyu Chen","orcid":"0000-0002-9496-8586","position":10,"is_corresponding":false},{"id":292753,"name":"Jennifer A. Lo","orcid":"0000-0002-9520-6874","position":11,"is_corresponding":false},{"id":29913,"name":"Xiao Wang","orcid":"0000-0002-3090-9894","position":12,"is_corresponding":false},{"id":984569,"name":"Hu Zeng","orcid":"0000-0003-4773-205X","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T01:06:25.560098Z","pmid":"37384709","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}