{"doi":"10.1126/science.abq3178","title":"Peptide YY: A Paneth cell antimicrobial peptide that maintains <i>Candida</i> gut commensalism","abstract":"The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY 1-36 ), but not endocrine PYY 3-36 , acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae—but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.","journal":"Science","year":2023,"id":316726,"datarank":0.6846522287201755,"base_score":4.564348191467836,"endowment":4.564348191467836,"self_citation_contribution":0.6846522287201755,"citation_network_contribution":0.0,"self_endowment_contribution":0.6846522287201755,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":95,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232320,"name":"Brian M. Peters","orcid":"0000-0002-0445-2077","position":1,"is_corresponding":false},{"id":1021846,"name":"Diana La Torre","orcid":null,"position":2,"is_corresponding":false},{"id":262010,"name":"Ashley M. Sidebottom","orcid":"0000-0002-8670-9090","position":3,"is_corresponding":false},{"id":1021012,"name":"Yiwei Tao","orcid":"0000-0003-4835-9576","position":4,"is_corresponding":false},{"id":377085,"name":"Xiaorong Zhu","orcid":"0000-0003-4528-0192","position":5,"is_corresponding":false},{"id":569870,"name":"Candace M. Cham","orcid":"0000-0001-7135-949X","position":6,"is_corresponding":false},{"id":1021013,"name":"Ling Wang","orcid":"0000-0001-9146-9047","position":7,"is_corresponding":false},{"id":848720,"name":"Amal Kambal","orcid":null,"position":8,"is_corresponding":false},{"id":230367,"name":"Katharine G. Harris","orcid":"0000-0001-6141-1207","position":9,"is_corresponding":false},{"id":1021014,"name":"Julian Furtado Silva","orcid":"0000-0002-1481-9303","position":10,"is_corresponding":false},{"id":263527,"name":"Olga Zaborina","orcid":"0000-0002-9316-7496","position":11,"is_corresponding":false},{"id":263529,"name":"John C. Alverdy","orcid":"0000-0003-1854-4551","position":12,"is_corresponding":false},{"id":121805,"name":"Herbert Herzog","orcid":null,"position":13,"is_corresponding":false},{"id":582510,"name":"Jessica N. Witchley","orcid":"0000-0001-9859-3411","position":14,"is_corresponding":false},{"id":582512,"name":"Suzanne M. Noble","orcid":"0000-0001-9855-8448","position":15,"is_corresponding":false},{"id":421994,"name":"Vanessa Leone","orcid":"0000-0003-4012-4377","position":16,"is_corresponding":false},{"id":109507,"name":"Eugene B. Chang","orcid":"0000-0001-5972-8248","position":17,"is_corresponding":false},{"id":305319,"name":"Joseph F. Pierre","orcid":"0000-0002-4248-1290","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:06:44.698773Z","pmid":"37535745","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}