{"doi":"10.1126/science.abn8897","title":"Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529","abstract":"The rapid spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (Omicron) variant and its resistance to neutralization by vaccinee and convalescent sera are driving a search for monoclonal antibodies with potent neutralization. To provide insight into effective neutralization, we determined cryo-electron microscopy structures and evaluated receptor binding domain (RBD) antibodies for their ability to bind and neutralize B.1.1.529. Mutations altered 16% of the B.1.1.529 RBD surface, clustered on an RBD ridge overlapping the angiotensin-converting enzyme 2 (ACE2)-binding surface and reduced binding of most antibodies. Substantial inhibitory activity was retained by select monoclonal antibodies-including A23-58.1, B1-182.1, COV2-2196, S2E12, A19-46.1, S309, and LY-CoV1404-that accommodated these changes and neutralized B.1.1.529. We identified combinations of antibodies with synergistic neutralization. The analysis revealed structural mechanisms for maintenance of potent neutralization against emerging variants.","journal":"Science","year":2022,"id":232606,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":180,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105588,"name":"Lingshu Wang","orcid":"0000-0002-8404-4910","position":1,"is_corresponding":false},{"id":302423,"name":"John Misasi","orcid":"0000-0001-7169-2639","position":2,"is_corresponding":false},{"id":266884,"name":"Amarendra Pegu","orcid":"0000-0003-3564-6453","position":3,"is_corresponding":false},{"id":105589,"name":"Yi Zhang","orcid":"0000-0002-8228-2560","position":4,"is_corresponding":false},{"id":842011,"name":"Darcy R. Harris","orcid":"0000-0002-3671-6452","position":5,"is_corresponding":false},{"id":229155,"name":"Adam S. 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