{"doi":"10.1126/science.abn0910","title":"Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure","abstract":"Tissue-tissue communication by endocrine factors is a vital mechanism for physiologic homeostasis. A systems genetics analysis of transcriptomic and functional data from a cohort of diverse, inbred strains of mice predicted that coagulation factor XI (FXI), a liver-derived protein, protects against diastolic dysfunction, a key trait of heart failure with preserved ejection fraction. This was confirmed using gain- and loss-of-function studies, and FXI was found to activate the bone morphogenetic protein (BMP)-SMAD1/5 pathway in the heart. The proteolytic activity of FXI is required for the cleavage and activation of extracellular matrix-associated BMP7 in the heart, thus inhibiting genes involved in inflammation and fibrosis. Our results reveal a protective role of FXI in heart injury that is distinct from its role in coagulation.","journal":"Science","year":2022,"id":233136,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":143,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9632,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":845792,"name":"Yuchen Wang","orcid":"0000-0001-5188-5222","position":1,"is_corresponding":false},{"id":277035,"name":"Zhenqi Zhou","orcid":"0000-0001-6560-9704","position":2,"is_corresponding":false},{"id":236692,"name":"Calvin Pan","orcid":"0000-0002-0752-833X","position":3,"is_corresponding":false},{"id":845793,"name":"Ling Jiang","orcid":"0000-0002-1003-850X","position":4,"is_corresponding":false},{"id":628284,"name":"Zhiqiang Zhou","orcid":"0000-0002-8914-0864","position":5,"is_corresponding":false},{"id":845794,"name":"Yonghong Meng","orcid":"0000-0003-2725-9648","position":6,"is_corresponding":false},{"id":391406,"name":"Sarada Charugundla","orcid":null,"position":7,"is_corresponding":false},{"id":435652,"name":"Tao Li","orcid":"0000-0002-7988-3090","position":8,"is_corresponding":false},{"id":236718,"name":"Hooman Allayee","orcid":"0000-0002-2384-5239","position":9,"is_corresponding":false},{"id":236691,"name":"Marcus Seldin","orcid":"0000-0001-8026-4759","position":10,"is_corresponding":false},{"id":15457,"name":"Aldons J. Lusis","orcid":"0000-0001-9013-0228","position":11,"is_corresponding":false},{"id":845791,"name":"Yang Cao","orcid":"0000-0003-2086-6314","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:21:25.223756Z","pmid":"36137043","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}