{"doi":"10.1126/science.abm5320","title":"The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication","abstract":"The tail of replication-dependent histone H3.1 varies from that of replication-independent H3.3 at the amino acid located at position 31 in plants and animals, but no function has been assigned to this residue to demonstrate a unique and conserved role for H3.1 during replication. We found that TONSOKU (TSK/TONSL), which rescues broken replication forks, specifically interacts with H3.1 via recognition of alanine 31 by its tetratricopeptide repeat domain. Our results indicate that genomic instability in the absence of ATXR5/ATXR6-catalyzed histone H3 lysine 27 monomethylation in plants depends on H3.1, TSK, and DNA polymerase theta (Pol θ). This work reveals an H3.1-specific function during replication and a common strategy used in multicellular eukaryotes for regulating post-replicative chromatin maturation and TSK, which relies on histone monomethyltransferases and reading of the H3.1 variant.","journal":"Science","year":2022,"id":236595,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":857473,"name":"Yi-Chun Huang","orcid":"0000-0002-7487-4443","position":1,"is_corresponding":false},{"id":465329,"name":"Benoît Mermaz","orcid":"0000-0002-2573-4401","position":2,"is_corresponding":false},{"id":241532,"name":"Chantal LeBlanc","orcid":"0000-0003-1173-3579","position":3,"is_corresponding":false},{"id":465328,"name":"Axel Poulet","orcid":"0000-0002-3415-8960","position":4,"is_corresponding":false},{"id":822780,"name":"Geoffrey Thomson","orcid":"0000-0003-0848-1550","position":5,"is_corresponding":false},{"id":465332,"name":"Valentin Joly","orcid":"0000-0001-9357-764X","position":6,"is_corresponding":false},{"id":717215,"name":"Marcelo Muñoz","orcid":"0000-0001-7748-4996","position":7,"is_corresponding":false},{"id":857474,"name":"Alexis Arvanitis-Vigneault","orcid":"0000-0002-3652-7467","position":8,"is_corresponding":false},{"id":857475,"name":"Devisree Valsakumar","orcid":"0000-0002-8279-6369","position":9,"is_corresponding":false},{"id":465330,"name":"Gonzalo Villarino","orcid":"0000-0003-2832-6785","position":10,"is_corresponding":false},{"id":858273,"name":"Alex Ross","orcid":null,"position":11,"is_corresponding":false},{"id":717217,"name":"Benjamin H. Rotstein","orcid":"0000-0001-9707-9357","position":12,"is_corresponding":false},{"id":717218,"name":"Emilio I. Alarcón","orcid":"0000-0001-5100-6179","position":13,"is_corresponding":false},{"id":563091,"name":"J.S. Brunzelle","orcid":"0000-0001-9197-0018","position":14,"is_corresponding":false},{"id":241536,"name":"Philipp Voigt","orcid":"0000-0003-4366-0490","position":15,"is_corresponding":false},{"id":465327,"name":"Jie Dong","orcid":"0000-0003-0493-1665","position":16,"is_corresponding":false},{"id":857476,"name":"Jean‐François Couture","orcid":"0000-0003-0385-4450","position":17,"is_corresponding":false},{"id":241530,"name":"Yannick Jacob","orcid":"0000-0003-4741-0755","position":18,"is_corresponding":false},{"id":857472,"name":"Hossein Davarinejad","orcid":"0000-0002-6049-1492","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T00:22:03.686498Z","pmid":"35298257","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}