{"doi":"10.1126/science.abj8754","title":"Accurate prediction of protein structures and interactions using a three-track neural network","abstract":"DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network architectures that incorporate related ideas and obtained the best performance with a three-track network in which information at the one-dimensional (1D) sequence level, the 2D distance map level, and the 3D coordinate level is successively transformed and integrated. The three-track network produces structure predictions with accuracies approaching those of DeepMind in CASP14, enables the rapid solution of challenging x-ray crystallography and cryo-electron microscopy structure modeling problems, and provides insights into the functions of proteins of currently unknown structure. The network also enables rapid generation of accurate protein-protein complex models from sequence information alone, short-circuiting traditional approaches that require modeling of individual subunits followed by docking. We make the method available to the scientific community to speed biological research.","journal":"Science","year":2021,"id":144960,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5780,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9455,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246362,"name":"Frank DiMaio","orcid":"0000-0002-7524-8938","position":1,"is_corresponding":false},{"id":105703,"name":"Ivan Anishchenko","orcid":"0000-0003-3645-2044","position":2,"is_corresponding":false},{"id":552413,"name":"Justas Dauparas","orcid":"0000-0002-0030-144X","position":3,"is_corresponding":false},{"id":56800,"name":"Sergey Ovchinnikov","orcid":"0000-0003-2774-2744","position":4,"is_corresponding":false},{"id":614113,"name":"Gyu Rie Lee","orcid":"0000-0002-9119-5303","position":5,"is_corresponding":false},{"id":552250,"name":"Jue Wang","orcid":"0000-0002-1139-6640","position":6,"is_corresponding":false},{"id":572645,"name":"Qian Cong","orcid":"0000-0002-8909-0414","position":7,"is_corresponding":false},{"id":233715,"name":"Lisa N. 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