{"doi":"10.1126/science.abh2623","title":"C(sp <sup>3</sup> )–H methylation enabled by peroxide photosensitization and Ni-mediated radical coupling","abstract":"Adding methyl groups with good timing In pharmaceutical research, swapping out hydrogens for methyl groups is a frequent strategy to optimize small-molecule properties. Vasilopoulos et al. report a versatile, convenient, and comparatively safe method for methylation of carbon centers adjacent to nitrogen or aryl rings. Under carefully optimized conditions, di-tert-butyl peroxide plays a dual role as oxidant and methyl source. Cleaving the O–O bond through photosensitization produces butoxyl radicals, some of which cleave substrate C–H bonds, whereas others release methyl radicals that a nickel catalyst delivers to those activated substrates. Science , this issue p. 398","journal":"Science","year":2021,"id":146504,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":215,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":246772,"name":"Shane W. Krska","orcid":"0000-0001-9757-9036","position":1,"is_corresponding":false},{"id":110277,"name":"Shannon S. Stahl","orcid":"0000-0002-9000-7665","position":2,"is_corresponding":false},{"id":279589,"name":"Aristidis Vasilopoulos","orcid":"0000-0001-7494-7801","position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-18T23:42:24.567796Z","pmid":"33888639","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}