{"doi":"10.1126/science.abg7917","title":"Plant “helper” immune receptors are Ca <sup>2+</sup> -permeable nonselective cation channels","abstract":"Calcium signaling for host cell death In response to microbial pathogens, some plants kill off their own cells to limit further spread of infection. The Toll/Interleukin-1 receptor/Resistance class of nucleotide-binding leucine-rich repeat receptors (known as TNLs) function in plants as immune receptors. These TNLs work together with a dedicated set of helper proteins. Jacob et al. reveal the structure of one of these helpers known as NRG1 (N REQUIREMENT GENE 1). The structure resembles a known animal cation channel. The authors demonstrate that helper NLRs directly control calcium ion influx to initiate host cell death, providing a mechanism for TNL outputs. Science , abg7917, this issue p. 420","journal":"Science","year":2021,"id":145505,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":389,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.953,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":617805,"name":"Nak Hyun Kim","orcid":"0000-0002-3722-1988","position":1,"is_corresponding":false},{"id":617806,"name":"Fei-Hua Wu","orcid":"0000-0002-5817-3831","position":2,"is_corresponding":false},{"id":30208,"name":"Farid El Kasmi","orcid":"0000-0002-4634-7689","position":3,"is_corresponding":false},{"id":617807,"name":"Yuan Chi","orcid":"0000-0002-9409-1614","position":4,"is_corresponding":false},{"id":245441,"name":"William G. Walton","orcid":"0000-0001-6745-534X","position":5,"is_corresponding":false},{"id":18790,"name":"Oliver J. Furzer","orcid":"0000-0002-3536-9970","position":6,"is_corresponding":false},{"id":617808,"name":"Adam D. Lietzan","orcid":"0000-0001-6388-2491","position":7,"is_corresponding":false},{"id":561952,"name":"Sruthi Sunil","orcid":"0000-0002-2142-5935","position":8,"is_corresponding":false},{"id":619435,"name":"Korina Kempthorn","orcid":null,"position":9,"is_corresponding":false},{"id":36347,"name":"Matthew R. Redinbo","orcid":"0000-0003-0814-5346","position":10,"is_corresponding":false},{"id":531861,"name":"Zhen‐Ming Pei","orcid":"0000-0003-1473-696X","position":11,"is_corresponding":false},{"id":74938,"name":"Li Wan","orcid":"0000-0002-0839-3748","position":12,"is_corresponding":false},{"id":18795,"name":"Jeffery L. Dangl","orcid":"0000-0003-3199-8654","position":13,"is_corresponding":false},{"id":617804,"name":"Pierre Jacob","orcid":"0000-0002-1253-3256","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-18T23:42:12.871665Z","pmid":"34140391","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}