{"doi":"10.1126/science.abg6130","title":"MBD5 and MBD6 couple DNA methylation to gene silencing through the J-domain protein SILENZIO","abstract":"methyl-CpG binding domain proteins, MBD5 and MBD6, that are recruited to chromatin by recognition of CG methylation, and redundantly repress a subset of genes and transposons without affecting DNA methylation levels. These methyl-readers recruit a J-domain protein, SILENZIO, that acts as a transcriptional repressor in loss-of-function and gain-of-function experiments. J-domain proteins often serve as co-chaperones with HSP70s. Indeed, we found that SILENZIO's conserved J-domain motif was required for its interaction with HSP70s and for its silencing function. These results uncover an unprecedented role of a molecular chaperone J-domain protein in gene silencing downstream of DNA methylation.","journal":"Science","year":2021,"id":150518,"datarank":0.6798899239729885,"base_score":4.532599493153256,"endowment":4.532599493153256,"self_citation_contribution":0.6798899239729885,"citation_network_contribution":0.0,"self_endowment_contribution":0.6798899239729885,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":92,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271912,"name":"Brandon A. Boone","orcid":"0000-0002-6475-8000","position":1,"is_corresponding":false},{"id":641260,"name":"Luke Strauskulage","orcid":null,"position":2,"is_corresponding":false},{"id":462130,"name":"C. Jake Harris","orcid":"0000-0001-5120-0377","position":3,"is_corresponding":false},{"id":362020,"name":"Gundeep Kaur","orcid":"0000-0003-3481-9527","position":4,"is_corresponding":false},{"id":640212,"name":"Matthew A. Gladstone","orcid":"0000-0003-1389-7382","position":5,"is_corresponding":false},{"id":641261,"name":"Maverick Tan","orcid":null,"position":6,"is_corresponding":false},{"id":268619,"name":"Suhua Feng","orcid":"0000-0001-6048-0083","position":7,"is_corresponding":false},{"id":344710,"name":"Yasaman Jami‐Alahmadi","orcid":"0000-0001-8289-2222","position":8,"is_corresponding":false},{"id":563282,"name":"Sascha H. Duttke","orcid":"0000-0003-4717-000X","position":9,"is_corresponding":false},{"id":14958,"name":"James A. Wohlschlegel","orcid":"0000-0003-3399-901X","position":10,"is_corresponding":false},{"id":356553,"name":"Xiaodong Cheng","orcid":"0000-0002-6967-6362","position":11,"is_corresponding":false},{"id":555960,"name":"Sy Redding","orcid":"0000-0003-3463-7985","position":12,"is_corresponding":false},{"id":225877,"name":"Steven E. Jacobsen","orcid":"0000-0001-9483-138X","position":13,"is_corresponding":false},{"id":640211,"name":"Lucia Ichino","orcid":"0000-0002-0559-1626","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:06.501849Z","pmid":"34083448","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}