{"doi":"10.1126/science.abg2752","title":"CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses","abstract":"The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph nodes, with CD5 expression on DCs correlating with patient survival. Activating CD5 on DCs enhanced T cell priming and improved survival after ICB therapy. CD5 + DC numbers increased during ICB therapy, and low interleukin-6 (IL-6) concentrations promoted their de novo differentiation. Mechanistically, CD5 expression by DCs was required to generate optimally protective CD5 hi T helper and CD8 + T cells; further, deletion of CD5 from T cells dampened tumor elimination in response to ICB therapy in vivo. Thus, CD5 + DCs are an essential component of optimal ICB therapy.","journal":"Science","year":2023,"id":316083,"datarank":0.7156026936698499,"base_score":4.770684624465665,"endowment":4.770684624465665,"self_citation_contribution":0.7156026936698499,"citation_network_contribution":0.0,"self_endowment_contribution":0.7156026936698499,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":117,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1018754,"name":"Kate Roussak","orcid":"0000-0001-5171-5864","position":1,"is_corresponding":false},{"id":236682,"name":"Feiyang Ma","orcid":"0000-0002-6260-0787","position":2,"is_corresponding":false},{"id":251348,"name":"Nicholas Borcherding","orcid":"0000-0003-1427-6342","position":3,"is_corresponding":false},{"id":1019320,"name":"Vince Garin","orcid":null,"position":4,"is_corresponding":false},{"id":630233,"name":"J. 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