{"doi":"10.1126/science.abf6648","title":"Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues","abstract":"Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, prepandemic children had class-switched convergent clones to severe acute respiratory syndrome coronavirus 2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. These results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.","journal":"Science","year":2021,"id":155500,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9518,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":237490,"name":"Sandra C. A. Nielsen","orcid":"0000-0003-4746-8287","position":1,"is_corresponding":false},{"id":237493,"name":"Ramona A. Hoh","orcid":"0000-0002-5116-1942","position":2,"is_corresponding":false},{"id":226825,"name":"Katharina Röltgen","orcid":"0000-0002-1582-1720","position":3,"is_corresponding":false},{"id":226827,"name":"Oliver F. Wirz","orcid":"0000-0003-0377-6464","position":4,"is_corresponding":false},{"id":265668,"name":"Emily Haraguchi","orcid":null,"position":5,"is_corresponding":false},{"id":237494,"name":"Grace H. Jean","orcid":"0000-0002-7991-7043","position":6,"is_corresponding":false},{"id":237495,"name":"Ji-Yeun Lee","orcid":"0000-0002-0463-6802","position":7,"is_corresponding":false},{"id":226835,"name":"Tho D. Pham","orcid":"0000-0002-5900-0289","position":8,"is_corresponding":false},{"id":237492,"name":"Katherine Jackson","orcid":"0000-0002-9952-7069","position":9,"is_corresponding":false},{"id":53910,"name":"Krishna M. Roskin","orcid":"0000-0002-5864-5093","position":10,"is_corresponding":false},{"id":658241,"name":"Yi Liu","orcid":"0000-0003-2745-6940","position":11,"is_corresponding":false},{"id":658242,"name":"Khoa D. Nguyen","orcid":"0000-0003-3149-3621","position":12,"is_corresponding":false},{"id":456410,"name":"Robert S. Ohgami","orcid":"0000-0003-1881-3440","position":13,"is_corresponding":false},{"id":562545,"name":"Eleanor M. Osborne","orcid":null,"position":14,"is_corresponding":false},{"id":36438,"name":"Kari C. Nadeau","orcid":"0000-0002-2146-2955","position":15,"is_corresponding":false},{"id":452818,"name":"Claus U. Niemann","orcid":"0000-0003-3701-6084","position":16,"is_corresponding":false},{"id":231939,"name":"Julie Parsonnet","orcid":"0000-0001-7342-5366","position":17,"is_corresponding":false},{"id":226844,"name":"Scott D. Boyd","orcid":"0000-0003-0963-044X","position":18,"is_corresponding":false},{"id":237491,"name":"Fan Yang","orcid":"0000-0003-4821-6583","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-18T23:44:03.750995Z","pmid":"33846272","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}