{"doi":"10.1126/science.abe9985","title":"Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women","abstract":"Anti-aging supplement effects in humans Synthesis of nicotinamide adenine dinucleotide (NAD + ) decreases during aging, which is thought to limit the activity of enzymes that require it for their catalytic activity. Studies in animals indicate that replenishment of cellular NAD + can have beneficial effects on aging and age-related diseases, but the situation in humans is less clear. Yoshino et al. report the effects of supplementation with the NAD + precursor nicotinamide mononucleotide in overweight or obese postmenopausal women with prediabetes (see the Perspective by Hepler and Bass). The treatment improved insulin sensitivity in muscle, although a change in NAD + content was not detected. The treatment also increased the expression of platelet-derived growth factor b. The results support potential therapeutic action of NAD + supplementation in humans, but how various NAD+ precursors are processed in specific tissues remains to be fully explored. Science , abe9985, this issue p. 1224 ; see also abj0764, p. 1147","journal":"Science","year":2021,"id":145446,"datarank":4.832365394120305,"base_score":6.040254711277414,"endowment":6.040254711277414,"self_citation_contribution":0.9060382066916122,"citation_network_contribution":3.9263271874286922,"self_endowment_contribution":0.9060382066916122,"citer_contribution":3.9263271874286922,"corpus_percentile":null,"corpus_rank":null,"citation_count":419,"citer_count":100,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9412,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03151239"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":240812,"name":"Jun Yoshino","orcid":"0000-0001-9833-4356","position":1,"is_corresponding":false},{"id":240811,"name":"Brandon D. Kayser","orcid":"0000-0003-1214-6069","position":2,"is_corresponding":false},{"id":186110,"name":"Gary J. Patti","orcid":"0000-0002-3748-6193","position":3,"is_corresponding":false},{"id":617509,"name":"Michael P. Franczyk","orcid":"0000-0002-3729-6365","position":4,"is_corresponding":false},{"id":321864,"name":"Kathryn F. Mills","orcid":null,"position":5,"is_corresponding":false},{"id":249607,"name":"Miriam Sindelar","orcid":"0000-0002-1700-6551","position":6,"is_corresponding":false},{"id":372174,"name":"Terri Pietka","orcid":"0000-0003-0160-7261","position":7,"is_corresponding":false},{"id":240817,"name":"Bruce W. Patterson","orcid":"0000-0001-9261-0233","position":8,"is_corresponding":false},{"id":320219,"name":"Shin‐ichiro Imai","orcid":"0000-0003-3742-5777","position":9,"is_corresponding":false},{"id":55892,"name":"Samuel Klein","orcid":"0000-0001-7127-1156","position":10,"is_corresponding":false},{"id":240810,"name":"Mihoko Yoshino","orcid":"0000-0003-4123-7699","position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":null,"created_at":"2026-07-18T23:42:12.871665Z","pmid":"33888596","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}