{"doi":"10.1126/science.abe7070","title":"The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage","abstract":"αβ and γδ T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of γμTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vγ-Cγ) γ-chain paired to a three-domain (Vμ-Vμj-Cμ) μ-chain. γμTCRs were characterized by restricted diversity in the Vγ and Vμj domains and a highly diverse unpaired Vμ domain. Crystal structures of two distinct γμTCRs revealed the structural basis of the association of the γμTCR heterodimer. The Vμ domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3μ loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the γμTCR.","journal":"Science","year":2021,"id":186163,"datarank":0.49983067652628066,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.0,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9563,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":345697,"name":"Marcin Wegrecki","orcid":"0000-0002-3275-9850","position":1,"is_corresponding":false},{"id":744163,"name":"T. Praveena","orcid":null,"position":2,"is_corresponding":false},{"id":743460,"name":"Victoria L. Hansen","orcid":"0000-0002-2653-7231","position":3,"is_corresponding":false},{"id":330984,"name":"Lijing Bu","orcid":"0000-0001-8625-2732","position":4,"is_corresponding":false},{"id":737860,"name":"Komagal Kannan Sivaraman","orcid":null,"position":5,"is_corresponding":false},{"id":277146,"name":"Samuel Darko","orcid":"0000-0002-9711-8122","position":6,"is_corresponding":false},{"id":277153,"name":"Daniel C. Douek","orcid":"0000-0001-5575-8634","position":7,"is_corresponding":false},{"id":256186,"name":"Jamie Rossjohn","orcid":"0000-0002-2020-7522","position":8,"is_corresponding":false},{"id":406634,"name":"Robert D. Miller","orcid":"0000-0002-8479-8819","position":9,"is_corresponding":false},{"id":293171,"name":"Jérôme Le Nours","orcid":"0000-0002-2221-7636","position":10,"is_corresponding":false},{"id":743459,"name":"Kimberly A. Morrissey","orcid":"0000-0002-3035-2985","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:48:42.632147Z","pmid":"33766885","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}