{"doi":"10.1126/science.abe5146","title":"Expression of Foxp3 by T follicular helper cells in end-stage germinal centers","abstract":"Regulating germinal center contraction Germinal centers (GCs) in secondary lymphoid organs are where mature B cells expand and differentiate. Although GC formation is well studied, the control of GC duration and contraction is less well understood. Using intravital imaging of mouse GCs and single-cell RNA sequencing, Jacobsen et al. report that T follicular helper (T FH ) cells are a critical player in this process. They found that some late-GC T FH cells upregulate the transcription factor FOXP3 and acquire a regulatory T cell–like phenotype. These cells are distinct from T follicular regulatory (T FR ) cells and, unlike T FR cells, are needed to shut down the GC reaction. Tweaking this process may be key to extending GC lifetimes and enhancing antibody responses in the context of vaccination. Science , abe5146, this issue p. eabe5146","journal":"Science","year":2021,"id":148232,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":132,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9519,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":273570,"name":"Wei Hu","orcid":"0000-0002-0392-6939","position":1,"is_corresponding":false},{"id":217900,"name":"Tiago B. R. Castro","orcid":"0000-0002-0359-0611","position":2,"is_corresponding":false},{"id":631535,"name":"Sigrid Solem","orcid":null,"position":3,"is_corresponding":false},{"id":630611,"name":"Alice Galante","orcid":"0000-0003-3512-5156","position":4,"is_corresponding":false},{"id":630612,"name":"Zeran Lin","orcid":"0000-0003-4418-2443","position":5,"is_corresponding":false},{"id":104317,"name":"Samuel J. Allon","orcid":"0000-0002-8381-3159","position":6,"is_corresponding":false},{"id":295162,"name":"Luka Mesin","orcid":"0000-0001-9852-6841","position":7,"is_corresponding":false},{"id":295160,"name":"Angelina M. Bilate","orcid":"0000-0003-4575-786X","position":8,"is_corresponding":false},{"id":630613,"name":"Ariën Schiepers","orcid":"0000-0002-5185-364X","position":9,"is_corresponding":false},{"id":1413,"name":"Alex K. Shalek","orcid":"0000-0001-5670-8778","position":10,"is_corresponding":false},{"id":90403,"name":"Alexander Y. Rudensky","orcid":"0000-0003-1280-2898","position":11,"is_corresponding":false},{"id":266895,"name":"Gabriel D. Victora","orcid":"0000-0001-8807-348X","position":12,"is_corresponding":false},{"id":630610,"name":"Johanne T. Jacobsen","orcid":"0000-0001-9757-1923","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-18T23:42:41.063423Z","pmid":"34437125","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}