{"doi":"10.1126/science.abe1707","title":"CARD8 is an inflammasome sensor for HIV-1 protease activity","abstract":"Eradicating the last vestiges of HIV After treatment with antiretroviral therapy, HIV-1 wild-type and escape variants can persist in a latent form, especially within CD4 + T cells, hindering efforts to eradicate the virus. Q. Wang et al. found that human CARD8, a member of the caspase recruitment domain (CARD)–containing family of innate immune sensors, is activatable by direct proteolysis of its N-terminus by HIV-1 protease. This cleavage should result in the programmed cell death of infected cells, but HIV-1 protease remains inactive and undetected as a subunit of the unprocessed Gag-Pol polyprotein. However, when infected cells were treated with non-nucleoside reverse transcriptase inhibitors, intracellular Gag-Pol dimerization was enhanced, resulting in CARD8-mediated caspase activation and pyroptosis. Targeting this pathway may be a promising way to eliminate residual HIV-1 in patients. Science , this issue p. eabe1707","journal":"Science","year":2021,"id":147451,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":158,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576120,"name":"Hongbo Gao","orcid":"0000-0003-2013-5298","position":1,"is_corresponding":false},{"id":576121,"name":"Kolin M. Clark","orcid":"0000-0003-3025-125X","position":2,"is_corresponding":false},{"id":334924,"name":"Christian Shema Mugisha","orcid":"0000-0002-0517-7986","position":3,"is_corresponding":false},{"id":562269,"name":"Keanu Davis","orcid":"0000-0002-4256-9911","position":4,"is_corresponding":false},{"id":227895,"name":"Jack Pengfei Tang","orcid":"0000-0003-4479-9638","position":5,"is_corresponding":false},{"id":576122,"name":"Gray H. Harlan","orcid":"0000-0002-5235-2644","position":6,"is_corresponding":false},{"id":227903,"name":"Carl J. DeSelm","orcid":"0000-0001-7645-5798","position":7,"is_corresponding":false},{"id":552303,"name":"Rachel M. Presti","orcid":"0000-0002-5469-0727","position":8,"is_corresponding":false},{"id":324222,"name":"Sebla B. Kutluay","orcid":"0000-0001-5549-7032","position":9,"is_corresponding":false},{"id":413853,"name":"Liang Shan","orcid":"0000-0002-8833-2514","position":10,"is_corresponding":false},{"id":627497,"name":"Qiankun Wang","orcid":"0000-0002-4390-4785","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:42:35.448762Z","pmid":"33542150","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}