{"doi":"10.1126/science.abb5916","title":"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders","abstract":"<jats:title>Selective destruction of senescent cells</jats:title>\n          <jats:p>\n            Senescent cells are associated with a variety of age-related medical conditions and thus have been proposed as potential targets for therapy, but we do not yet have a full understanding of the underlying mechanisms. Johmura\n            <jats:italic>et al.</jats:italic>\n            used RNA interference to screen for enzymes essential to the survival of senescent cells (see the Perspective by Pan and Locasale). The authors identified a key role for glutamine metabolism, particularly the enzyme glutaminase 1, and demonstrated that inhibition of this pathway induced the death of senescent cells. Glutaminase targeting also ameliorated aging-related organ dysfunction and obesity-related disorders in mouse models, suggesting the potential therapeutic value of this approach.\n          </jats:p>\n          <jats:p>\n            <jats:italic>Science</jats:italic>\n            , this issue p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6526\" page=\"265\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126/science.abb5916\">265</jats:related-article>\n            ; see also p.\n            <jats:related-article xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" issue=\"6526\" page=\"234\" related-article-type=\"in-this-issue\" vol=\"371\" xlink:href=\"10.1126/science.abf6368\">234</jats:related-article>\n          </jats:p>","journal":"Science","year":2021,"id":13861,"datarank":7.39198848272463,"base_score":6.049733455231958,"endowment":6.049733455231958,"self_citation_contribution":0.9074600182847938,"citation_network_contribution":6.484528464439836,"self_endowment_contribution":0.9074600182847938,"citer_contribution":6.484528464439836,"corpus_percentile":null,"corpus_rank":null,"citation_count":423,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":6,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":112016,"name":"Takehiro Yamanaka","orcid":"0000-0003-3714-2697","position":1,"is_corresponding":false},{"id":112017,"name":"Satotaka Omori","orcid":"0000-0002-0423-7289","position":2,"is_corresponding":false},{"id":112018,"name":"Teh-Wei Wang","orcid":"0000-0001-9874-2392","position":3,"is_corresponding":false},{"id":112019,"name":"Yuki Sugiura","orcid":"0000-0002-6983-8958","position":4,"is_corresponding":false},{"id":112020,"name":"Masaki Matsumoto","orcid":"0000-0002-6987-0288","position":5,"is_corresponding":false},{"id":112021,"name":"Narumi Suzuki","orcid":"0000-0001-6024-9949","position":6,"is_corresponding":false},{"id":112022,"name":"Soichiro Kumamoto","orcid":"0000-0002-3492-117X","position":7,"is_corresponding":false},{"id":112023,"name":"Kiyoshi Yamaguchi","orcid":"0000-0003-2113-4369","position":8,"is_corresponding":false},{"id":112024,"name":"Seira Hatakeyama","orcid":"0000-0002-5726-3317","position":9,"is_corresponding":false},{"id":112025,"name":"Tomoyo Takami","orcid":"0000-0002-6974-8119","position":10,"is_corresponding":false},{"id":14241,"name":"Rui Yamaguchi","orcid":"0000-0003-1224-227X","position":11,"is_corresponding":false},{"id":14047,"name":"Eigo Shimizu","orcid":"0000-0002-2486-2321","position":12,"is_corresponding":false},{"id":112026,"name":"Kazutaka Ikeda","orcid":"0000-0001-9247-4593","position":13,"is_corresponding":false},{"id":112027,"name":"Nobuyuki Okahashi","orcid":"0000-0001-9582-355X","position":14,"is_corresponding":false},{"id":112028,"name":"Ryuta Mikawa","orcid":"0000-0003-0006-9051","position":15,"is_corresponding":false},{"id":112029,"name":"Makoto Suematsu","orcid":"0000-0002-7165-6336","position":16,"is_corresponding":false},{"id":112030,"name":"Makoto Arita","orcid":"0000-0001-9902-0463","position":17,"is_corresponding":false},{"id":112031,"name":"Masataka Sugimoto","orcid":"0000-0001-8737-8097","position":18,"is_corresponding":false},{"id":112032,"name":"Keiichi I. Nakayama","orcid":"0000-0002-7185-1529","position":19,"is_corresponding":false},{"id":112033,"name":"Yoichi Furukawa","orcid":"0000-0003-0462-8631","position":20,"is_corresponding":false},{"id":112034,"name":"Seiya Imoto","orcid":"0000-0002-2989-308X","position":21,"is_corresponding":false},{"id":112035,"name":"Makoto Nakanishi","orcid":"0000-0002-6707-3584","position":22,"is_corresponding":false},{"id":112015,"name":"Yoshikazu Johmura","orcid":"0000-0002-6812-9607","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.049733455231958,"endowment":6.049733455231958,"datacite_reuse_total":6,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33446552","pmcid":null,"openalex_id":"https://openalex.org/W3120626955","authors":[],"funders":[{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"JP17cm0106122, JP17fk0310111, and JP17gm5010001","title":null},{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"JP19gm5010003","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP26250027, JP22118003, and JP16K15239","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"JP18H05026m, JP16H06148, and JP16K15238","title":null},{"funder_name":"Princess Takamatsu Cancer Research Fund","grant_id":"","title":null},{"funder_name":"Relay for Life Japan Cancer Society","grant_id":"","title":null},{"funder_name":"Ono Medical Research Foundation","grant_id":"","title":null}],"total_grants":7,"fwci":37.4697,"citation_percentile":0.99907632,"influential_citations":15,"citation_trend":[{"year":2021,"count":50},{"year":2022,"count":76},{"year":2023,"count":83},{"year":2024,"count":98},{"year":2025,"count":84},{"year":2026,"count":32}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://syndication.highwire.org/content/doi/10.1126/science.abb5916","host_type":"publisher"},{"url":"https://www.science.org/doi/pdf/10.1126/science.abb5916","host_type":"publisher"},{"url":"https://doi.org/10.1126/science.abb5916","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33446552","host_type":"repository"}],"fields_of_study":["Telomeres, Telomerase, and Senescence","Advanced Glycation End Products research","RNA regulation and disease","Medicine","Biology","Adipose Tissue","Aging","Ammonia","Animals","Cell Survival","Cellular Senescence","Genes, Essential","Glutaminase","Humans","Hydrogen-Ion Concentration","Lung","Male","Mice","Mice, Inbred C57BL","Skin"],"mesh_terms":["Adipose Tissue","Aging","Ammonia","Animals","Cell Survival","Glutaminase","Humans","Hydrogen-Ion Concentration","Lung","Male","Mice, Inbred C57BL","Skin","Cellular Senescence","Genes, Essential","Mice"],"keywords":["Glutaminolysis","Chemistry","Biochemistry","Glycolysis","Metabolism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.18094446.v1","title":"Additional file 1 of The landscape of human tissue and cell type specific expression and co-regulation of senescence genes","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.18094446","title":"Additional file 1 of The landscape of human tissue and cell type specific expression and co-regulation of senescence genes","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26590631.v1","title":"Additional file 1 of Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.26590631","title":"Additional file 1 of Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.18094452.v1","title":"Additional file 2 of The landscape of human tissue and cell type specific expression and co-regulation of senescence genes","publisher":"figshare","resource_type":"Dataset"},{"doi":"10.6084/m9.figshare.18094452","title":"Additional file 2 of The landscape of human tissue and cell type specific expression and co-regulation of senescence genes","publisher":"figshare","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-05-31T19:19:50.326875Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}