{"doi":"10.1126/science.aba8740","title":"The histone H3-H4 tetramer is a copper reductase enzyme","abstract":"Enzymatic activity of histones Eukaryotic histones serve as structural elements to package DNA. However, they contain a copper-binding site for which the biological relevance is unknown. Copper homeostasis is critical for several fundamental eukaryotic processes, including mitochondrial respiration. Attar et al. hypothesized that histones may play a critical role in cellular copper utilization (see the Perspective by Rudolph and Luger). Using a multifaceted approach ranging from in vitro biochemistry to in vivo genetic and molecular analyses, they found that the histone H3-H4 tetramer is an oxidoreductase enzyme that catalyzes reduction of cupric ions, thereby providing biologically usable cuprous ions for various cellular processes. This work opens a new front for chromatin biology, with implications for eukaryotic evolution and human biology and disease. Science , this issue p. 59 ; see also p. 33","journal":"Science","year":2020,"id":53365,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":118,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":271906,"name":"Oscar A. Campos","orcid":"0000-0002-5645-7275","position":1,"is_corresponding":false},{"id":271907,"name":"Maria Vogelauer","orcid":"0000-0003-1360-0526","position":2,"is_corresponding":false},{"id":271908,"name":"Chen Cheng","orcid":"0000-0002-9610-1345","position":3,"is_corresponding":false},{"id":271909,"name":"Yong Xue","orcid":"0000-0002-7229-7232","position":4,"is_corresponding":false},{"id":271910,"name":"Stefan Schmollinger","orcid":"0000-0002-7487-8014","position":5,"is_corresponding":false},{"id":30375,"name":"Łukasz Salwiński","orcid":"0000-0003-4522-1969","position":6,"is_corresponding":false},{"id":271911,"name":"Nathan V. Mallipeddi","orcid":"0000-0003-2193-5932","position":7,"is_corresponding":false},{"id":271912,"name":"Brandon A. Boone","orcid":"0000-0002-6475-8000","position":8,"is_corresponding":false},{"id":271913,"name":"Linda Yen","orcid":"0000-0002-3331-1484","position":9,"is_corresponding":false},{"id":271914,"name":"Sichen Yang","orcid":"0000-0001-8421-3633","position":10,"is_corresponding":false},{"id":271915,"name":"Shannon Zikovich","orcid":"0000-0002-5498-3140","position":11,"is_corresponding":false},{"id":271916,"name":"Jade Dardine","orcid":"0000-0001-5671-9290","position":12,"is_corresponding":false},{"id":37940,"name":"Michael Carey","orcid":"0000-0003-3899-6280","position":13,"is_corresponding":false},{"id":271917,"name":"Sabeeha Merchant","orcid":"0000-0002-2594-509X","position":14,"is_corresponding":false},{"id":271918,"name":"Siavash K. Kurdistani","orcid":"0000-0003-3295-3511","position":15,"is_corresponding":false},{"id":271905,"name":"Narsis Attar","orcid":"0000-0002-5847-7587","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T20:44:25.349797Z","pmid":"32631887","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}