{"doi":"10.1126/science.aba6146","title":"Diverse functionalization of strong alkyl C–H bonds by undirected borylation","abstract":"The selective functionalization of strong, typically inert carbon-hydrogen (C-H) bonds in organic molecules is changing synthetic chemistry. However, the undirected functionalization of primary C-H bonds without competing functionalization of secondary C-H bonds is rare. The borylation of alkyl C-H bonds has occurred previously with this selectivity, but slow rates required the substrate to be the solvent or in large excess. We report an iridium catalyst ligated by 2-methylphenanthroline with activity that enables, with the substrate as limiting reagent, undirected borylation of primary C-H bonds and, when primary C-H bonds are absent or blocked, borylation of strong secondary C-H bonds. Reactions at the resulting carbon-boron bond show how these borylations can lead to the installation of a wide range of carbon-carbon and carbon-heteroatom bonds at previously inaccessible positions of organic molecules.","journal":"Science","year":2020,"id":49876,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":224,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242486,"name":"Bo Su","orcid":"0000-0002-1184-0828","position":1,"is_corresponding":false},{"id":242487,"name":"Isaac Furay Yu","orcid":"0000-0001-9659-2204","position":2,"is_corresponding":false},{"id":242488,"name":"Christian Ehinger","orcid":"0000-0003-2013-7429","position":3,"is_corresponding":false},{"id":242489,"name":"Erik A. Romero","orcid":"0000-0002-5155-1684","position":4,"is_corresponding":false},{"id":242490,"name":"Sam He","orcid":"0009-0006-9921-0092","position":5,"is_corresponding":false},{"id":242491,"name":"John F. Hartwig","orcid":"0000-0002-4157-468X","position":6,"is_corresponding":false},{"id":242485,"name":"Raphael J. Oeschger","orcid":"0000-0002-5209-1595","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-18T20:37:28.027635Z","pmid":"32409470","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}