{"doi":"10.1126/science.aba4937","title":"Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites","abstract":"Trunk formation in a dish Building mammalian embryos from self-organizing stem cells in culture would accelerate the investigation of morphogenetic and differentiation processes that shape the body plan. Veenvliet et al. report a method for generating embryonic trunk-like structures (TLSs) with a neural tube, somites, and gut by embedding mouse embryonic stem cell aggregates in an extracellular matrix surrogate. Live imaging and comparative single-cell transcriptomics indicate that TLS formation is analogous to mouse development. TLSs therefore provide a scalable, tractable, and accessible high-throughput platform for decoding mammalian embryogenesis at a high level of resolution. Science , this issue p. eaba4937","journal":"Science","year":2020,"id":48811,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":340,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9537,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":232555,"name":"Adriano Bolondi","orcid":"0000-0002-1096-9435","position":1,"is_corresponding":false},{"id":13682,"name":"Helene Kretzmer","orcid":"0000-0002-0723-4980","position":2,"is_corresponding":false},{"id":234447,"name":"Leah Haut","orcid":null,"position":3,"is_corresponding":false},{"id":234448,"name":"Manuela Scholze‐Wittler","orcid":null,"position":4,"is_corresponding":false},{"id":232556,"name":"Dennis Schifferl","orcid":"0000-0003-3507-5734","position":5,"is_corresponding":false},{"id":31013,"name":"Frédéric Koch","orcid":"0000-0002-0142-2411","position":6,"is_corresponding":false},{"id":232557,"name":"Léo Guignard","orcid":"0000-0002-3686-1385","position":7,"is_corresponding":false},{"id":74331,"name":"Abhishek Sampath Kumar","orcid":"0000-0001-7918-6706","position":8,"is_corresponding":false},{"id":232558,"name":"Milena Pustet","orcid":"0000-0003-3825-6530","position":9,"is_corresponding":false},{"id":232559,"name":"Simon Heimann","orcid":"0000-0001-8647-1644","position":10,"is_corresponding":false},{"id":232560,"name":"René Buschow","orcid":"0000-0002-9800-2578","position":11,"is_corresponding":false},{"id":31003,"name":"Lars Wittler","orcid":"0000-0001-7873-6702","position":12,"is_corresponding":false},{"id":234449,"name":"Bernd Timmermann","orcid":null,"position":13,"is_corresponding":false},{"id":769,"name":"Alexander Meissner","orcid":"0000-0001-8646-7469","position":14,"is_corresponding":false},{"id":31011,"name":"Bernhard G. Herrmann","orcid":"0000-0002-2192-8188","position":15,"is_corresponding":false},{"id":232554,"name":"Jesse V. Veenvliet","orcid":"0000-0002-1191-2975","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-18T20:35:18.908826Z","pmid":"33303587","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}